Tetrahydrofuran

CAS 109-99-9C4H8OBiochemicals & Reagents

Tetrahydrofuran (CAS: 109-99-9, Formula: C4H8O) is a heterocyclic organic compound with a molar mass of 72.11 g/mol. This versatile solvent is characterised by its low viscosity and miscibility with water and many organic solvents. It is widely employed as a reaction medium, a solvent for polymers, and a component in chromatographic mobile phases, particularly in high-performance liquid chromatography (HPLC).

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Tetrahydrofuran (C4H8O) — chemical structure, CAS 109-99-9; Life Science, fine chemical supplied by Tech Serve Solutions

Amino Acid AnalysisAmino Acid Analysis ReagentsBiochemicals and ReagentsPeptides

01 /Applications

HPLC Mobile Phase Component

Tetrahydrofuran serves as a mobile-phase component in the HPLC analysis of triglycerides. Its properties facilitate effective separation and detection of these lipid molecules.

Reaction Solvent

Its excellent solvating capabilities make it a preferred solvent for various organic reactions, including Grignard reactions and polymerizations. It effectively dissolves a wide range of organic compounds and polymers.

Polymer Solvent

Tetrahydrofuran is a valuable solvent for many polymers, including PVC, polyurethanes, and natural resins. It is used in the manufacturing and processing of these materials.

02 /Properties

Molecular weight	72.11
Empirical formula	C4H8O
Assay	≥99.5% (GC)
Boiling point	65-67 °C(lit.)
Density	0.889 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.407(lit.)n20/D 1.407
Vapour pressure	114 mmHg (15 °C)143 mmHg (20 °C)
Melting point	−108 °C(lit.)
Vapour density	2.5 (vs air)
Autoignition temp	610 °F
Application	Mobile-phase component in the HPLC analysis of triglycerides1,2.
Suitability	in accordance for luminescence

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H225Highly flammable liquid and vapour
H319Causes serious eye irritation
H335May cause respiratory irritation
H351Suspected of causing cancer

Precautionary statements

P210Keep away from heat, sparks and open flames. No smoking
P261Avoid breathing dust, fume, gas or vapours
P281Use personal protective equipment as required
P305IF IN EYES

Protective equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	-17 °C / 1.4 °F
Transport (UN / ADR)	UN 2056 3 / PGII
Water hazard class (WGK, DE)	1
Hazard codes (EU)	F,Xn
Risk statements (R)	11-19-36/37-40
Safety statements (S)	13-16-29-33-36-37-46
Supplemental hazards	May form explosive peroxides.

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

109-99-9

MDL number

MFCD00005356

Beilstein registry

102391

05 /Additional specifications

Uv Absorption	λ: 240 nm Amax: 0.3λ: 250 nm Amax: 0.2λ: 260 nm Amax: 0.1λ: 280 nm Amax: 0.03λ: 310 nm Amax: 0.003

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Tetrahydrofuran (CAS: 109-99-9) used for?

Tetrahydrofuran (CAS: 109-99-9) is primarily used as a reaction solvent, a solvent for polymers, and as a mobile-phase component in HPLC analysis, particularly for triglycerides.

What are the CAS number and formula for Tetrahydrofuran?

The CAS number for Tetrahydrofuran is 109-99-9, and its empirical formula (Hill notation) is C4H8O.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Tetrahydrofuran with an assay of ≥99.5% (GC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.

How should Tetrahydrofuran be handled safely?

Tetrahydrofuran is a highly flammable liquid and vapour (H225) and can cause serious eye irritation (H319) and respiratory irritation (H335). It is suspected of causing cancer (H351) and may form explosive peroxides. Handle with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, in a well-ventilated area away from ignition sources. Store away from oxidising agents and prevent peroxide formation.

How is Tetrahydrofuran packed, shipped, and exported?

Tetrahydrofuran is packed and shipped in accordance with international regulations for hazardous materials, including UN 2056, Class 3, Packing Group II. Tech Serve Solutions is experienced in global export.