tert-Butyllithium solution
Tert-Butyllithium solution (CAS 594-19-4), with the linear formula (CH3)3CLi and a molecular weight of 64.06 g/mol, is a highly reactive organolithium compound. It serves as a potent base and nucleophile in organic synthesis. Typically supplied as a 1.5 M solution in pentane, it is crucial for deprotonation reactions and in the generation of carbanions for various synthetic transformations, particularly in the pharmaceutical and fine chemical industries.
- IUPAC
- Lithium-2-methyl-2-propanide,t-BuLi
- Synonyms
- Lithium 2-methyl-2-propanidet-BuLi
Deprotonation Agent
Tert-Butyllithium is a strong, sterically hindered base used for the selective deprotonation of weakly acidic protons. Its bulkiness often prevents unwanted side reactions, making it ideal for generating specific carbanions or enolates.
Organometallic Synthesis
As an organolithium reagent, it participates in the formation of new carbon-carbon bonds through reactions with electrophiles. This is fundamental in constructing complex organic molecules.
Polymerisation Initiator
In certain polymerisation processes, tert-butyllithium can act as an initiator, particularly in anionic polymerisation, to control polymer architecture and molecular weight.
Research and Development
It is widely employed in academic and industrial research laboratories for exploring novel synthetic routes and developing new chemical entities.
| Molecular weight | 64.06 |
|---|---|
| Linear formula | (CH3)3CLi |
| Concentration | 1.5 M in pentane |
Hazard statements
- H225Highly flammable liquid and vapour
- H250Catches fire spontaneously if exposed to air
- H260In contact with water releases flammable gases
- H304May be fatal if swallowed and enters airways
- H314Causes severe skin burns and eye damage
- H336May cause drowsiness or dizziness
- H410Very toxic to aquatic life with long-lasting effects
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -4 °C / 24.8 °F |
| Transport (UN / ADR) | UN 3394 4.2/PG 1 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,C,N |
| Risk statements (R) | 11-14/15-17-34-50/53-65-67 |
| Safety statements (S) | 26-36/37/39-43-45-61-62 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Tert-Butyllithium solution used for?
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Tert-Butyllithium solution is primarily used as a strong base for deprotonation reactions, in the generation of carbanions for C-C bond formation, and as an initiator in certain polymerisation processes. It is a key reagent in organic synthesis.
What is the CAS number and formula for Tert-Butyllithium solution?
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The CAS number for Tert-Butyllithium solution is 594-19-4, and its linear formula is (CH3)3CLi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Tert-Butyllithium solution typically as a 1.5 M solution in pentane. We do not claim USP, BP, or EP grades unless explicitly stated in the product specification. For detailed purity, please refer to the certificate of analysis.
How is Tert-Butyllithium solution handled and stored?
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Tert-Butyllithium solution is extremely flammable and pyrophoric, reacting violently with water and air, and is corrosive. It requires handling under an inert atmosphere (e.g., nitrogen or argon) in a well-ventilated area, using appropriate personal protective equipment including flame-retardant clothing, gloves, and eye protection. Store in tightly sealed containers away from heat, sparks, and open flames, and incompatible materials.
How is this product packed, shipped, and exported?
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This product is packed in specialised containers suitable for pyrophoric and flammable liquids, adhering to international transport regulations. Tech Serve Solutions is experienced in exporting hazardous chemicals globally.
How can I request a sample or quote for Tert-Butyllithium solution?
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To request a sample or a quote, please contact our sales team via the website or provide your details through the product inquiry form, specifying the quantity and any other requirements.
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