Sulindac
Sulindac (CAS 38194-50-2), a non-steroidal anti-inflammatory drug (NSAID) with the molecular formula C20H17FO3S and a molecular weight of 356.41, is utilised for its chemopreventive and antitumor properties. It is recognised for its ability to increase the cytotoxicity of certain chemotherapeutic agents. Sulindac also exhibits binding to human plasma proteins and affects heat-induced denaturation of albumin.
- IUPAC
- (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
- Synonyms
- (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
Chemotherapeutic Agent Adjuvant
Sulindac can significantly enhance the cytotoxicity of anthracyclines like doxorubicin, daunorubicin, and epirubicin. It also potentiates the effects of teniposide, VP-16, and vincristine, making it a valuable adjunct in cancer research and therapeutic strategies.
Antitumor Research
Research indicates Sulindac's role in increasing the expression of MRP1 and MRP3 in human colorectal cancer cell lines. This mechanism contributes to its potential as an antitumor agent and warrants further investigation in cancer therapy.
Biochemical Research
Sulindac is employed in biochemical studies to investigate protein interactions, such as its binding to human plasma proteins and its effects on albumin denaturation <i>in vitro</i>.
| Molecular weight | 356.41 |
|---|---|
| Empirical formula | C20H17FO3S |
| Assay | ≥98.0% |
| Application | Treatment of human colorectal cancer cell lines induces MRP1 and MRP3 but not other members of the MRP family. Reported to significantly increase the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine. Sulindac was tested for its effect on heat-induced denaturation of albumin in vitro28 and its ability to bind to human plasma protein.29 |
| Suitability | meets USP testing specifications |
Hazard statements
- H301Toxic if swallowed
- H317May cause an allergic skin reaction
- H334May cause allergy or asthma symptoms if inhaled
- H361Suspected of damaging fertility or the unborn child
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P342
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 63-22-42/43 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ALB(213), PTGS2(5743) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sulindac used for?
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Sulindac is used in research for its chemopreventive and antitumor properties, as an adjuvant to enhance the efficacy of certain chemotherapy drugs, and in biochemical studies investigating protein interactions.
What is the CAS number and molecular formula for Sulindac?
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The CAS number for Sulindac is 38194-50-2 and its molecular formula is C20H17FO3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Sulindac with an assay of ≥98.0%. It meets USP testing specifications. We do not represent it as USP, BP, or EP grade.
How should Sulindac be handled safely?
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Sulindac is classified as toxic if swallowed and can cause allergic skin reactions and respiratory irritation. It may also damage fertility or the unborn child. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area. Refer to the Safety Data Sheet for full handling instructions.
Is Sulindac a controlled substance?
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The provided data does not indicate that Sulindac is a controlled substance.
How is Sulindac packed, shipped, and exported?
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Sulindac is packed securely and is available for domestic and international export by Tech Serve Solutions, adhering to all relevant shipping regulations for hazardous materials (UN 2811, 6.1 / PGIII).
How can I request a quote or sample of Sulindac?
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To request a quote or sample of Sulindac, please contact our sales team via the website or by calling us directly.
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