SB 431542 hydrate

CAS 301836-41-9 (anhydrous)C22H16N4O3 · xH2OCell Biology

SB 431542 hydrate (CAS: 301836-41-9) is a chemical compound with the formula C22H16N4O3 · xH2O and a molecular weight of 384.39 g/mol (anhydrous basis). This hydrate is primarily recognised for its role as a selective inhibitor of the transforming growth factor-beta (TGF-β) type I receptor kinases, ALK4, ALK5, and ALK7. It is widely employed in biological research for investigating cellular signalling pathways, particularly those involving TGF-β.

IUPAC: 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate,4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate,4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
Synonyms: 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate,4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate,4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate

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SB 431542 hydrate (C22H16N4O3 · xH2O) — chemical structure, CAS 301836-41-9 (anhydrous); Life Science, fine chemical supplied by Tech Serve Solutions

Cell BiologyCytokines and Growth FactorsCytokinesGrowth Factors and HormonesGlaxoSmithKlineKinase/Phosphatase BiologyTGF-β Inhibitors

01 /Applications

Investigating TGF-β Signalling Pathways

SB-431542 is utilised to study the role of TGF-β signalling in various biological processes, including cell differentiation and the modulation of the extracellular matrix in research settings.

Cancer Research

This compound has been applied in research to examine the correlation between platelet-derived growth factor receptor B expression and TGF-β pathway activation within colorectal tumour cells.

Cell Biology Studies

SB-431542 serves as a valuable tool in cell biology for exploring fundamental cellular mechanisms and responses influenced by TGF-β signalling.

02 /Properties

Molecular weight	384.39 (anhydrous basis)
Empirical formula	C22H16N4O3 · xH2O
Assay	≥98% (HPLC)
Form	powder
Solubility	DMSO: soluble10 mg/mLH2O: insoluble
Storage temperature	−20°C
Application	SB-431542 was used to study the correlation of platelet-derived growth factor receptor B expression and TGF-β pathway activation in colorectal tumor cells.1 It was used to study the role of TGF-β signaling in modulation of extracellular matrix2 and myoblast differentiation.3

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

301836-41-9 (anhydrous)

MDL number

MFCD11045982

PubChem substance

24724609

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is SB 431542 hydrate used for?

SB 431542 hydrate is used in research to study the TGF-β signalling pathway, its role in cell differentiation, extracellular matrix modulation, and its involvement in conditions such as colorectal tumour cell growth.

What is the CAS number and formula for SB 431542 hydrate?

The CAS number for the anhydrous form is 301836-41-9. The empirical formula is C22H16N4O3 · xH2O.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies SB 431542 hydrate with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should SB 431542 hydrate be handled and stored?

Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The compound should be stored at −20°C. It is soluble in DMSO but insoluble in water. Please consult the Safety Data Sheet for comprehensive handling information.