SB 415286
SB 415286 (CAS: 264218-23-7), a small molecule inhibitor with the formula C16H10N3O5Cl and a molecular weight of 359.72 g/mol, is a research chemical used in biochemical and cell biology studies. It functions as a selective inhibitor of Glycogen Synthase Kinase 3 (GSK3). This compound has been utilised in research to investigate the role of GSK-3 in cellular processes, including cell proliferation in neuroblastoma models.
- IUPAC
- 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione
GSK-3 Inhibition Studies
SB 415286 is a potent inhibitor of Glycogen Synthase Kinase 3 (GSK3), making it valuable for research into the biological roles of this enzyme. It allows scientists to probe GSK3 signalling pathways.
Cellular Proliferation Research
Studies have employed SB 415286 to examine the impact of GSK-3 inhibition on cell proliferation. For example, it was used to treat neuroblastoma cells to understand these effects.
Neuroscience Research Tool
As a molecule affecting cell signaling, SB 415286 can serve as a tool in neuroscience research, particularly in studies related to GSK3's role in neuronal function and development.
| Molecular weight | 359.72 |
|---|---|
| Empirical formula | C16H10N3O5Cl |
| Assay | ≥98% (HPLC) |
| Colour | yellow to orange |
| Solubility | DMSO: soluble16 mg/mLH2O: insoluble |
| Storage temperature | −20°C |
| Application | SB 415289 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.1 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... GSK3A(2931), GSK3B(2932) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is SB 415286 used for?
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SB 415286 is primarily used as a research chemical to study the inhibition of Glycogen Synthase Kinase 3 (GSK3) and its effects on cell proliferation and signaling pathways, particularly in cell biology and neuroscience research.
What is the CAS number and formula for SB 415286?
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The CAS number for SB 415286 is 264218-23-7, and its empirical formula is C16H10N3O5Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies SB 415286 with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
What are the safety considerations when handling SB 415286?
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SB 415286 is classified as a Warning substance, with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be worn. Handle in a well-ventilated area.
How is SB 415286 packaged and shipped?
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SB 415286 is typically stored at -20°C. Tech Serve Solutions can export this chemical globally, adhering to all relevant shipping regulations for research chemicals.
How can I request a sample or quote for SB 415286?
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To request a sample or a quote for SB 415286, please contact our sales team via the website or through the provided contact details. We will respond promptly to your inquiry.
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