(S)-5-Azido-2-(Fmoc-amino)pentanoic acid
(S)-5-Azido-2-(Fmoc-amino)pentanoic acid (CAS: 1097192-04-5; Formula: C20H20N4O4; MW: 380.40) is a protected amino acid derivative featuring an azide functional group. This compound serves as a valuable building block in organic synthesis, particularly for peptide chemistry and bioconjugation. Its structure allows for facile introduction of azide moieties, which can subsequently undergo click chemistry reactions, making it instrumental in areas like chemical biology and drug discovery.
- IUPAC
- Fmoc-5-azido-L-norvaline,Fmoc-L-δ-azidoornithine,Fmoc-Orn(N2)-OH
- Synonyms
- Fmoc-5-azido-L-norvalineFmoc-L-δ-azidoornithineFmoc-Orn(N2)-OH
Peptide Synthesis
This Fmoc-protected amino acid is utilized in solid-phase or solution-phase peptide synthesis to incorporate an azide functionality into peptide chains. The azide group can be used for post-translational modification mimicry or as a handle for subsequent bioorthogonal reactions.
Bioconjugation Chemistry
The compound is a key reagent for bioconjugation, enabling the attachment of biomolecules to surfaces or other molecules via click chemistry (e.g., copper-catalyzed or strain-promoted azide-alkyne cycloaddition). This is crucial for developing diagnostic tools, therapeutic conjugates, and imaging agents.
Organic Synthesis Building Block
As an organic building block, it provides a versatile route to synthesize complex molecules containing both amino acid and azide functionalities. The Fmoc protecting group facilitates controlled synthetic pathways.
Chemical Biology Research
It is employed in chemical biology to label and study biological systems. The azide group allows for selective tagging of proteins or other biomolecules, aiding in the elucidation of cellular processes and drug target identification.
| Molecular weight | 380.40 |
|---|---|
| Empirical formula | C20H20N4O4 |
| Assay | ≥97.0% (HPLC) |
| Optical activity | [α]/D 3.5±0.3°, c = 1 in ethyl acetate |
| Storage temperature | 2-8°C |
| Composition | carbon, 62.5-63.9%nitrogen, 14.3-15.1% |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (S)-5-Azido-2-(Fmoc-amino)pentanoic acid used for?
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(S)-5-Azido-2-(Fmoc-amino)pentanoic acid is primarily used as a building block in peptide synthesis and bioconjugation chemistry, allowing for the introduction of azide functionalities for subsequent bioorthogonal reactions like click chemistry.
What is the CAS number and formula for (S)-5-Azido-2-(Fmoc-amino)pentanoic acid?
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The CAS number is 1097192-04-5 and the empirical formula is C20H20N4O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (S)-5-Azido-2-(Fmoc-amino)pentanoic acid with a purity of ≥97.0% (HPLC). This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
What are the safety and handling precautions for this chemical?
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This compound is classified as a Warning hazard. It can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is (S)-5-Azido-2-(Fmoc-amino)pentanoic acid packed and shipped?
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This chemical is typically stored at 2-8°C. Packaging and shipping procedures comply with all relevant regulations for chemical substances, ensuring safe transport and export globally by Tech Serve Solutions.
How can I request a sample or quote?
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To request a sample or a quotation for (S)-5-Azido-2-(Fmoc-amino)pentanoic acid, please contact our sales team through the website or by phone.
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