O-tert-Butylhydroxylamine hydrochloride
O-tert-Butylhydroxylamine hydrochloride (CAS 39684-28-1) is a fine chemical building block with the linear formula (CH3)3CONH2·HCl and a molecular weight of 125.60. This compound serves as a key reactant in the synthesis of various biologically active molecules and complex organic structures. Its utility spans the development of pharmaceutical agents, including MMP inhibitors and antimalarial treatments, as well as in specialised organic transformations like Weinreb amide equivalents and photocycloadditions.
- IUPAC
- 2-Aminooxy-2-methylpropane hydrochloride,O-(1,1-Dimethylethyl)hydroxylamine hydrochloride,tert-Butoxyamine hydrochloride
- Synonyms
- 2-Aminooxy-2-methylpropane hydrochlorideO-(1,1-Dimethylethyl)hydroxylamine hydrochloridetert-Butoxyamine hydrochloride
Synthesis of Biologically Active Molecules
O-tert-Butylhydroxylamine hydrochloride is utilised as a reactant in the synthesis of molecules with potential therapeutic applications, such as CGS 25966 derivatives investigated as MMP inhibitors and imidazolidinedione derivatives explored for antimalarial treatments.
Development of P2Y6 Receptor Agonists
This compound is employed in the creation of pyrimidine ribonucleotide analogs designed to act as P2Y6 receptor agonists, contributing to research in cellular signalling pathways.
Inhibition of Protein Isoprenylation
It functions as a reactant in syntheses targeting Rab proteins, aiming for inhibition of isoprenylation and geranylgeranylation processes which are critical in cellular function.
Preparation of Weinreb Amide Equivalents
The chemical is used in the synthesis of N-(arylethyl)-O-tert-butylhydroxamates, which serve as versatile equivalents to Weinreb amides in organic synthesis.
Advanced Organic Transformations
It participates in reactions such as double allylic alkylation of indole-2-hydroxamates, SN2 substitutions at amide nitrogens, and photocycloaddition reactions to C=N bonds for synthesizing 1,3-diazepines.
| Molecular weight | 125.60 |
|---|---|
| Linear formula | (CH3)3CONH2 · HCl |
| Assay | ≥99.0% (AT) |
| Solubility | H2O: soluble0.5 g/10 mL |
| Application | Reactant involved in synthesis of biologically active molecules including:• CGS 25966 derivatives for use as MMP inhibitors1• Imidazolidinedione derivatives for use as antimalarial treatments2• Pyrimidine ribonucleotide analogs as P2Y6 receptor agonists3• Rab proteins for isoprenylation and geranylgeranylation inhibition4Reactant involved in:• Synthesis of N-(arylethyl)-O-tert-butylhydroxamates for use as Weinreb amide equivalents5• Double allylic alkylation of indole-2-hydroxamates6• SN2 substitution reactions at amide nitrogens7• Photocycloaddition to C=N bonds for synthesis of 1,3-diazepines8 |
| Melting point | ~155 °C (dec.) |
Hazard statements
- H228Flammable solid
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1325 4.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-tert-Butylhydroxylamine hydrochloride used for?
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O-tert-Butylhydroxylamine hydrochloride is primarily used as a reactant in the synthesis of biologically active molecules, including MMP inhibitors, antimalarial agents, P2Y6 receptor agonists, and in various organic transformations like the preparation of Weinreb amide equivalents.
What are the CAS number and formula for O-tert-Butylhydroxylamine hydrochloride?
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The CAS number is 39684-28-1, and the linear formula is (CH3)3CONH2·HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies O-tert-Butylhydroxylamine hydrochloride with a purity of ≥99.0% (AT). This product is supplied for laboratory and research purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should O-tert-Butylhydroxylamine hydrochloride be handled safely?
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O-tert-Butylhydroxylamine hydrochloride is classified as a flammable solid (H228) and requires careful handling. Recommended personal protective equipment includes eyeshields, gloves, and appropriate respiratory protection such as a full-face particle respirator (type N100 US) or P3 (EN143) filter cartridges. It should be kept away from heat and ignition sources, adhering to precautionary statement P210.
Is O-tert-Butylhydroxylamine hydrochloride a controlled substance?
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The provided data does not indicate that O-tert-Butylhydroxylamine hydrochloride is a controlled substance.
How is O-tert-Butylhydroxylamine hydrochloride shipped and exported?
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O-tert-Butylhydroxylamine hydrochloride is classified as UN 1325, Hazard Class 4.1, Packing Group III, for transport. Tech Serve Solutions, as a specialist global supplier and exporter, handles all necessary documentation and compliance for international shipments.
How can I request a sample or quote for O-tert-Butylhydroxylamine hydrochloride?
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To request a sample or a quotation, please contact the Tech Serve Solutions sales team through the website's contact form or by calling our dedicated sales line.
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