Rolipram

CAS 61413-54-5C16H21NO3Biochemicals & Reagents

Rolipram (CAS 61413-54-5), with the molecular formula C16H21NO3 and a molecular weight of 275.34 g/mol, is a white to off-white solid. This compound is primarily recognised as a selective inhibitor of phosphodiesterase IV (PDE4). It is widely employed in biochemical research for its ability to modulate cyclic adenosine monophosphate (cAMP) levels. Rolipram serves as a crucial tool in studying cellular signalling pathways, particularly in neuroscience and inflammation research.

IUPAC: 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone,ZK 62711

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Rolipram (C16H21NO3) — chemical structure, CAS 61413-54-5; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyCyclic Nucleotide MetabolismEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesP to Q

01 /Applications

Phosphodiesterase IV Inhibition

Rolipram is a potent and selective inhibitor of the phosphodiesterase IV enzyme. This action leads to an increase in intracellular cyclic AMP (cAMP) levels, impacting various cellular processes.

Neuroscience Research

Its ability to modulate cAMP signalling makes Rolipram valuable in neuroscientific studies, investigating its potential effects on neuronal function, neuroprotection, and mood regulation.

Inflammation and Immunology Studies

Rolipram has been used as a research tool to explore the role of PDE4 and cAMP in inflammatory responses, aiding in the understanding of immune cell activation and cytokine production.

Cell Signalling Investigations

As a modulator of the cAMP pathway, Rolipram is instrumental in dissecting complex cell signalling cascades in various biological systems and cell types.

02 /Properties

Molecular weight	275.34
Empirical formula	C16H21NO3
Assay	≥98% (HPLC)
Form	solid
Colour	white to off-white
Solubility	H2O: soluble0.2 mg/mLethanol: soluble7 mg/mLDMSO: soluble7.3 mg/mL

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

61413-54-5

MDL number

MFCD00270906

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Rolipram used for?

Rolipram is primarily used as a selective inhibitor of phosphodiesterase IV (PDE4) in biochemical and cellular research. It helps researchers investigate the roles of cyclic AMP (cAMP) in cellular signalling, neuroscience, and inflammatory processes.

What is the CAS number and chemical formula for Rolipram?

The CAS number for Rolipram is 61413-54-5, and its chemical formula is C16H21NO3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Rolipram with an assay of ≥98% (HPLC). This is a research-grade chemical and is not represented as USP, BP, EP, or any other pharmacopoeial grade.

How should Rolipram be handled safely?

Rolipram is classified as a Warning substance with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). When handling, use a dust mask type N95 (US), wear eyeshields and gloves. Ensure adequate ventilation.

Is Rolipram available for export?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and Rolipram can be shipped internationally. Please contact us for export details and quotations.