Ro 31-0432

CAS 145333-02-4C28H28N4O2 · HClBiochemicals & Reagents

Ro 31-0432 (CAS: 145333-02-4), a bisindoylmaleimide derivative with the molecular formula C28H28N4O2 · HCl and a molecular weight of 489.01 g/mol, is supplied as an orange solid. This compound serves as a potent and selective inhibitor of protein kinase C (PKC) and other related kinases. It is commonly utilised in biochemical research for investigating cell signalling pathways and enzyme inhibition mechanisms.

IUPAC: 3-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methylindol-3-yl)maleimide hydrochloride,3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride,Bisindoylmaleimide XI
Synonyms: Bisindoylmaleimide XI

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Ro 31-0432 (C28H28N4O2 · HCl) — chemical structure, CAS 145333-02-4; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymesInhibitorsand SubstratesKinase/Phosphatase BiologyL to O

01 /Applications

Protein Kinase C Inhibition

Ro 31-0432 acts as a selective inhibitor of Protein Kinase C (PKC), making it a valuable tool for studying the role of these enzymes in cellular processes. It allows researchers to probe signalling cascades dependent on PKC activity.

Cell Signalling Research

This compound is employed in the investigation of complex cell signalling pathways, particularly those involving kinases. Its specificity allows for targeted studies into the effects of kinase modulation on cellular behaviour and function.

Enzyme Inhibition Studies

As a well-characterised enzyme inhibitor, Ro 31-0432 is used in biochemical assays to understand enzyme kinetics and inhibition mechanisms. It aids in the development and validation of assays for kinase activity.

02 /Properties

Molecular weight	489.01
Empirical formula	C28H28N4O2 · HCl
Form	solid
Colour	orange
Solubility	DMSO: soluble5 mg/mLH2O: insoluble
Storage temperature	−20°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

145333-02-4

05 /Additional specifications

Storage Condition	protect from light

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Ro 31-0432 used for?

Ro 31-0432 is used in biochemical research as a selective inhibitor of protein kinase C (PKC) and related kinases, aiding in the study of cell signalling pathways and enzyme inhibition.

What is the CAS number and molecular formula for Ro 31-0432?

The CAS number for Ro 31-0432 is 145333-02-4, and its molecular formula is C28H28N4O2 · HCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Ro 31-0432 as a research-grade chemical. The exact assay or purity is available on the product's specification sheet. We do not represent this product as meeting pharmacopoeial standards such as USP, BP, or EP.

What are the safety precautions for handling Ro 31-0432?

When handling Ro 31-0432, it is essential to use appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The compound is classified with a WGK Germany of 3, indicating a hazard to water. Handle with care to prevent environmental release.

How is Ro 31-0432 packed, shipped, and exported?

Ro 31-0432 is typically packed in appropriate containers to ensure stability and safety during transport. Tech Serve Solutions exports fine chemicals globally, adhering to all relevant shipping regulations.

How can I request a sample or quote for Ro 31-0432?

To request a sample or a quotation for Ro 31-0432, please contact our sales team through the website or by phone, providing your contact details and required quantity.