(R)-(+)-o-Tolyl-CBS-oxazaborolidine solution
(R)-(+)-o-Tolyl-CBS-oxazaborolidine solution (CAS: 865812-10-8, C24H24BNO) is a crucial chiral catalyst utilised in asymmetric synthesis. Supplied as a 0.5 M solution in toluene, this compound, when activated, generates chiral Lewis acids essential for enantioselective reactions. Its application is pivotal in producing stereochemically pure compounds, particularly in the pharmaceutical and fine chemical industries.
- IUPAC
- (R)-(+)-3,3-Diphenyl-1-o-tolyl-tetrahydropyrrolo(1,2-c)(1,3,2)oxazaborole
Asymmetric Synthesis
This oxazaborolidine acts as a precursor to chiral Lewis acids, enabling enantioselective transformations. It is particularly valuable in reactions requiring high stereochemical control.
Chiral Catalyst
As a key chiral catalyst, it facilitates the synthesis of enantiomerically enriched molecules. Its application is critical in processes demanding specific stereoisomers.
Reduction Reactions
In its activated form, this reagent can be employed in enantioselective reduction processes, contributing to the synthesis of chiral alcohols and other reduction products.
| Molecular weight | 353.26 |
|---|---|
| Empirical formula | C24H24BNO |
| Density | 0.900 g/mL at 25 °C |
| Refractive index | n20/D 1.514 |
| Concentration | 0.5 M in toluene |
| Application | When protonated with trifluoromethanesulfonimide, chiral oxazaborolidines generate chiral Lewis acids, which have demonstrated great utility in the enantioselective Diels-Alder reaction.1,2 |
Hazard statements
- H225Highly flammable liquid and vapour
- H304May be fatal if swallowed and enters airways
- H315Causes skin irritation
- H336May cause drowsiness or dizziness
- H361D
- H373May cause damage to organs through prolonged exposure
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P301IF SWALLOWED
- P331Do NOT induce vomiting
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 4 °C / 39.2 °F |
| Transport (UN / ADR) | UN 1294 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 63-11-38-48/20-65-67 |
| Safety statements (S) | 16-36/37-62 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-o-Tolyl-CBS-oxazaborolidine solution used for?
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(R)-(+)-o-Tolyl-CBS-oxazaborolidine solution is primarily used as a precursor to chiral Lewis acids in asymmetric synthesis, particularly for enantioselective Diels-Alder reactions and reduction processes.
What are the CAS number and formula for (R)-(+)-o-Tolyl-CBS-oxazaborolidine solution?
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The CAS number is 865812-10-8, and the empirical formula (Hill notation) is C24H24BNO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in toluene. TSS does not represent this product as USP, BP, or EP grade.
How should (R)-(+)-o-Tolyl-CBS-oxazaborolidine solution be handled safely?
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This product is highly flammable and may be harmful if swallowed or inhaled. Handle with extreme care, using appropriate personal protective equipment including safety glasses, gloves, and a respirator, in a well-ventilated area, away from ignition sources.
Is this product suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and can arrange for the export of (R)-(+)-o-Tolyl-CBS-oxazaborolidine solution.
How can I request a sample or quote?
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To request a sample or a quote for (R)-(+)-o-Tolyl-CBS-oxazaborolidine solution, please contact our sales team via the website or direct email.
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