(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether (CAS 1236033-34-3), with the molecular formula C23H33NOSi, is a chiral organocatalyst. This silyl-protected proline derivative is primarily employed in asymmetric synthesis, facilitating enantioselective reactions. Its defined stereochemistry makes it a valuable tool for chemists developing stereospecific synthetic routes in pharmaceutical and fine chemical research.
- IUPAC
- (R)-2-[(tert-Butyldimethylsiloxy)diphenylmethyl]pyrrolidine,(R)-Diphenylprolinol tert-butyldimethylsilyl ether
- Synonyms
- (R)-2- [(tert-Butyldimethylsiloxy)diphenylmethyl]pyrrolidine(R)-Diphenylprolinol tert-butyldimethylsilyl ether
Asymmetric Catalysis
This compound serves as a chiral catalyst in various asymmetric transformations, enabling the selective formation of one enantiomer over the other. Its structure is derived from proline, a common motif in organocatalysis.
Chiral Ligand Development
It can be used as a building block or precursor in the synthesis of more complex chiral ligands for metal-catalyzed asymmetric reactions. The defined stereogenic centre is crucial for inducing enantioselectivity.
Pharmaceutical Intermediate Synthesis
In research and development settings, this reagent is utilised for the stereocontrolled synthesis of complex molecules that may serve as pharmaceutical intermediates. Its application aids in the efficient generation of enantiomerically pure compounds.
Stereoselective Organic Reactions
The molecule's inherent chirality makes it suitable for promoting a range of stereoselective organic reactions, contributing to the synthesis of enantiopure fine chemicals and advanced materials.
| Molecular weight | 367.60 |
|---|---|
| Empirical formula | C23H33NOSi |
| Assay | ≥97% (HPLC) |
| Optical purity | enantiomeric excess: ≥98.0% |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether used for?
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This compound is primarily used in asymmetric synthesis as a chiral catalyst or building block for chiral ligands, facilitating enantioselective reactions in the development of pharmaceuticals and fine chemicals.
What are the CAS number and formula for this compound?
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The CAS number is 1236033-34-3, and its empirical formula is C23H33NOSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥97% (HPLC) and an optical purity (enantiomeric excess) of ≥98.0%. This product is suitable for research and chemical synthesis purposes and is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the main hazards associated with this chemical?
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This compound is classified as a Warning, with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment should be worn during handling.
How is this chemical packed and shipped?
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Tech Serve Solutions packs and exports fine chemicals globally, adhering to international shipping regulations for hazardous materials to ensure safe and compliant delivery.
How can I request a sample or quote for this product?
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To request a sample or a quotation, please use the 'Request a Quote' or 'Sample Request' feature on our website or contact our sales team directly with your inquiry, referencing the product name and CAS number.
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