3,3-Difluoropyrrolidine hydrochloride
3,3-Difluoropyrrolidine hydrochloride (CAS: 163457-23-6) is a fluorinated heterocyclic building block with the molecular formula C4H7F2N · HCl and a molecular weight of 143.56 g/mol. This compound serves as a valuable intermediate in organic synthesis, particularly for the introduction of the difluoropyrrolidine moiety into more complex molecular structures. Its applications are primarily found within the fine chemical and pharmaceutical research sectors for novel compound development.
- Synonyms
- C4H7F2N · HCl

Fluorinated Heterocycle Synthesis
Utilised as a key building block in the synthesis of novel fluorinated heterocyclic compounds. These structures are of interest in medicinal chemistry due to the unique properties fluorine imparts.
Pharmaceutical Intermediate
Serves as a crucial intermediate in the development of new pharmaceutical candidates. The difluoropyrrolidine core can be incorporated into molecules designed for therapeutic applications.
Organic Synthesis Reagent
Employed in complex organic syntheses requiring the specific incorporation of a difluorinated pyrrolidine ring. Facilitates the creation of diverse chemical entities for research purposes.
| Molecular weight | 143.56 |
|---|---|
| Empirical formula | C4H7F2N · HCl |
| Assay | 97% |
| Melting point | 133-136 °C |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,3-Difluoropyrrolidine hydrochloride used for?
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3,3-Difluoropyrrolidine hydrochloride is primarily used as a building block in organic synthesis and as an intermediate in the development of new pharmaceutical candidates and other complex fluorinated heterocyclic compounds.
What is the CAS number and formula for 3,3-Difluoropyrrolidine hydrochloride?
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The CAS number is 163457-23-6 and the empirical formula is C4H7F2N · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,3-Difluoropyrrolidine hydrochloride with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
How should 3,3-Difluoropyrrolidine hydrochloride be handled?
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Handling requires a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation, and avoid breathing dust. In case of contact with eyes, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do. Continue rinsing.
Is 3,3-Difluoropyrrolidine hydrochloride a controlled substance?
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The provided data does not indicate that 3,3-Difluoropyrrolidine hydrochloride is a controlled substance.
How is this chemical packed, shipped, and exported?
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This chemical is carefully packed according to industry standards for safe transport and is available for global export by Tech Serve Solutions.
How can I request a quote or sample?
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Please contact our sales department via the website or direct email to request a quote or a sample of 3,3-Difluoropyrrolidine hydrochloride.
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