(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol (CAS 22348-32-9) is a chiral organic compound with the molecular formula C17H19NO. This high-purity (98%) chemical, also known as (R)-2-(Diphenylhydroxymethyl)pyrrolidine, is primarily utilised in asymmetric synthesis. It serves as a key precursor for preparing oxazaborolidines, essential reagents for the stereoselective reduction of ketones using borane.
- IUPAC
- α,α-Diphenyl-D-prolinol,(R)-2-(Diphenylhydroxymethyl)pyrrolidine
- Synonyms
- α,α-Diphenyl-D-prolinol(R)-2-(Diphenylhydroxymethyl)pyrrolidine
Asymmetric Synthesis
This compound is instrumental in asymmetric synthesis, particularly for the preparation of chiral intermediates. It is used to form oxazaborolidines, which are crucial in stereoselective reactions.
Chiral Ligand Precursor
It functions as a precursor for chiral ligands, which are vital in enantioselective catalysis. The stereochemical integrity of the molecule allows for the directed synthesis of specific enantiomers.
Organocatalysis
As a proline-based organocatalyst derivative, it can be employed in various catalytic asymmetric transformations, promoting enantioselectivity in organic reactions.
| Molecular weight | 253.34 |
|---|---|
| Empirical formula | C17H19NO |
| Assay | 98% |
| Optical activity | [α]20/D +69°, c = 3 in chloroform |
| Application | Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.1 |
| Melting point | 77-80 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol used for?
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(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol is used in asymmetric synthesis to prepare oxazaborolidines, which are then employed for the borane-mediated asymmetric reduction of ketones.
What is the CAS number and molecular formula for this compound?
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The CAS number is 22348-32-9, and the molecular formula is C17H19NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 98%. It is a research-grade chemical and is not supplied as USP, BP, EP, or pharmacopoeia grade.
How should (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol be handled safely?
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This compound is a Warning substance, classified with H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask (N95 or equivalent), eyeshields, and gloves. Ensure adequate ventilation.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures secure packaging suitable for international shipment of fine chemicals. Specific packing details are confirmed upon order.
How can I request a sample or quote for (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol?
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To request a sample or obtain a quote, please use the contact form on our website or call our sales team, referencing the product name and CAS number 22348-32-9.
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