(R)-(−)-O-Formylmandeloyl chloride
(R)-(−)-O-Formylmandeloyl chloride (CAS: 29169-64-0) is a chiral acid halide with the linear formula HCO₂CH(C₆H₅)COCl and a molecular weight of 198.60 g/mol. This compound serves as a valuable building block in asymmetric synthesis and organic chemical synthesis. It is particularly useful as a derivatization reagent for analytical purposes, especially in chromatography and UV-VIS detection, enabling the analysis of various compounds.
- IUPAC
- (−)-O-Formyl-D-mandeloyl chloride,(R)-(−)-α-(Formyloxy)phenylacetyl chloride
- Synonyms
- (−)-O-Formyl-D-mandeloyl chloride(R)−(α-(Formyloxy)phenyl)acetyl chloride(R)-α-(formyl-oxy)-benzeneacetic acid chloride
Chiral Building Block
(R)-(−)-O-Formylmandeloyl chloride is employed in asymmetric synthesis as a chiral precursor for constructing complex molecules with defined stereochemistry. Its inherent chirality makes it a useful starting material for enantioselective transformations.
Derivatization Reagent
This compound is frequently used as a derivatization reagent in analytical chemistry, particularly for High-Performance Liquid Chromatography (HPLC) and UV-VIS spectroscopy. Derivatization can enhance detectability and facilitate the separation of target analytes.
Organic Synthesis Intermediate
As a reactive acid halide, it participates in various organic synthesis reactions, acting as an intermediate for the formation of esters, amides, and other functional groups within broader synthetic strategies.
| Molecular weight | 198.60 |
|---|---|
| Linear formula | HCO2CH(C6H5)COCl |
| Assay | 97% |
| Boiling point | 221 °C(lit.) |
| Density | 1.275 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.523(lit.) |
| Optical activity | [α]23/D −228°, neat |
| Storage temperature | 2-8°C |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-O-Formylmandeloyl chloride used for?
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It is used as a chiral building block in asymmetric synthesis, an intermediate in organic synthesis, and a derivatization reagent for analytical techniques like HPLC and UV-VIS spectroscopy.
What is the CAS number and molecular formula for (R)-(−)-O-Formylmandeloyl chloride?
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The CAS number is 29169-64-0, and its linear formula is HCO₂CH(C₆H₅)COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-O-Formylmandeloyl chloride with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How is (R)-(−)-O-Formylmandeloyl chloride handled and stored?
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This compound is classified as Danger, causing severe skin burns and eye damage (H314). It requires protective equipment including a full-face respirator, gloves, and goggles. Store in a cool place at 2-8°C.
How is (R)-(−)-O-Formylmandeloyl chloride packed and shipped?
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As a global supplier and exporter, Tech Serve Solutions ensures appropriate packaging and shipping for (R)-(−)-O-Formylmandeloyl chloride, adhering to international regulations for hazardous materials (UN 3265 8 / PGII).
How can I request a quote or sample?
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Please contact our sales team to request a quote or a sample of (R)-(−)-O-Formylmandeloyl chloride. Our representatives will assist you with your inquiry.
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