(R)-(+)-N-(1-Phenylethyl)phthalamic acid
(R)-(+)-N-(1-Phenylethyl)phthalamic acid (CAS: 21752-35-2) is a chiral carboxylic acid with a molecular weight of 269.30 g/mol. It is an essential reagent in asymmetric synthesis and chemical manufacturing. This compound serves as a valuable chiral resolving agent for the separation of enantiomers, particularly amines, contributing to the production of stereochemically pure compounds vital in pharmaceuticals and fine chemical industries.
- IUPAC
- (R)-(+)-N-(α-Methylbenzyl)phthalamic acid,(R)-(+)-N-(α-Methylbenzyl)phthalic acid monoamide
![(R)-(+)-N-(1-Phenylethyl)phthalamic acid (2-[C6H5CH(CH3)NHCO]C6H4CO2H) — chemical structure, CAS 21752-35-2; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F21752-35-2.png&w=3840&q=75)
Chiral Resolution
Utilised as a chiral resolving agent, (R)-(+)-N-(1-Phenylethyl)phthalamic acid is effective in separating racemic mixtures of amines into their individual enantiomers. This process is critical for obtaining enantiomerically pure compounds, especially in pharmaceutical synthesis.
Asymmetric Synthesis
As a chiral building block, it plays a significant role in asymmetric synthesis. It can be incorporated into synthetic routes to introduce chirality or to direct stereoselective transformations, leading to the creation of complex chiral molecules.
Organic Synthesis Intermediate
This compound functions as a versatile intermediate in organic synthesis. Its structure allows for further chemical modifications, making it a useful precursor for a variety of organic compounds and functionalised molecules.
| Molecular weight | 269.30 |
|---|---|
| Linear formula | 2-[C6H5CH(CH3)NHCO]C6H4CO2H |
| Assay | 97% |
| Optical activity | [α]24/D +46°, c = 2 in ethanol |
| Application | Acid for the resolution of amines.1,2 |
| Melting point | 130-135 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-N-(1-Phenylethyl)phthalamic acid used for?
+
(R)-(+)-N-(1-Phenylethyl)phthalamic acid is primarily used as an acid for the resolution of amines, acting as a chiral resolving agent in asymmetric synthesis and as an organic building block.
What is the CAS number and formula for (R)-(+)-N-(1-Phenylethyl)phthalamic acid?
+
The CAS number is 21752-35-2, and its linear formula is 2-[C6H5CH(CH3)NHCO]C6H4CO2H.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies (R)-(+)-N-(1-Phenylethyl)phthalamic acid with an assay of 97%. TSS does not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for this chemical?
+
This compound is classified as a warning. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Ensure adequate ventilation and avoid breathing dust.
How is (R)-(+)-N-(1-Phenylethyl)phthalamic acid typically packed and shipped?
+
While specific packaging details vary, TSS ensures products are securely packed for export according to international regulations. Please contact us for detailed information on shipping and export capabilities.
How can I request a sample or quote?
+
To request a sample or a quote for (R)-(+)-N-(1-Phenylethyl)phthalamic acid, please use the contact form on our website or reach out to our sales team directly.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis