(R)-(−)-Glycidyl benzyl ether
(R)-(−)-Glycidyl benzyl ether (CAS: 14618-80-5) is a chiral epoxide with the molecular formula C10H12O2 and a molecular weight of 164.20 g/mol. This organic building block is valuable in asymmetric synthesis, serving as a precursor in the preparation of complex molecules. Its primary applications lie in the synthesis of pharmaceutical intermediates and other chiral compounds requiring specific stereochemistry.
- IUPAC
- (R)-(−)-2-(Benzyloxymethyl)oxirane
- Synonyms
- (R)-(−)-2-(Benzyloxymethyl)oxirane
Preparation of Lactone Fragments
Used in the preparation of the lactone fragment of compactin and mevinolin, important cholesterol-lowering agents.
Synthesis of Chiral Polyols
Serves as a chiral building block in the preparation of syn-1,3-polyols, crucial structural motifs in various natural products and pharmaceuticals.
Dideoxynucleoside Synthesis
Employed in the synthesis of dideoxynucleosides, which are vital components in antiviral therapies.
Spiroacetal Cyanohydrin Preparation
Utilised in the synthesis of a spiroacetal cyanohydrin, a complex structural unit found in certain bioactive molecules.
| Molecular weight | 164.20 |
|---|---|
| Empirical formula | C10H12O2 |
| Assay | 99% |
| Density | 1.077 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.517(lit.) |
| Optical activity | [α]20/D −5.4°, c = 5 in toluene |
| Storage temperature | 2-8°C |
| Application | Used in the preparation of the lactone fragment of compactin and mevinolin.1 Chiron in the preparation of syn-1,3-polyols,2 dideoxynucleosides,3 and a spiroacetal cyanohydrin.4 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-Glycidyl benzyl ether used for?
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(R)-(−)-Glycidyl benzyl ether is used in asymmetric synthesis, particularly in the preparation of lactone fragments for compactin and mevinolin, and in the synthesis of syn-1,3-polyols, dideoxynucleosides, and spiroacetal cyanohydrins.
What are the CAS number and formula for (R)-(−)-Glycidyl benzyl ether?
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The CAS number for (R)-(−)-Glycidyl benzyl ether is 14618-80-5, and its molecular formula is C10H12O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-Glycidyl benzyl ether with an assay of 99%. TSS does not represent this product as USP, BP, or EP grade.
How should (R)-(−)-Glycidyl benzyl ether be handled safely?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation and use a suitable respirator if airborne concentrations are high. It is classified as a warning substance due to skin, eye, and respiratory irritation.
How is (R)-(−)-Glycidyl benzyl ether packed and shipped?
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(R)-(−)-Glycidyl benzyl ether is typically stored at 2-8°C. TSS complies with all regulations for the packing, shipping, and export of chemical products.
How can I request a sample or quote for (R)-(−)-Glycidyl benzyl ether?
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Please contact our sales team to request a sample or a formal quotation for (R)-(−)-Glycidyl benzyl ether.
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