(R)-(+)-3-Butyn-2-ol
(R)-(+)-3-Butyn-2-ol (CAS: 42969-65-3, Formula: HC≡CCH(OH)CH3) is a chiral propargylic alcohol and an important organic building block. With a molecular weight of 70.09 g/mol, this compound is utilized in asymmetric synthesis and the preparation of novel chemical entities. Its structure makes it a valuable intermediate for creating more complex molecules, particularly in areas like pharmaceutical research where specific stereochemistry is crucial for biological activity.
Synthesis of 5-Lipoxygenase Inhibitors
Propargylic alcohols, including (R)-(+)-3-Butyn-2-ol, serve as key starting materials for the development of new classes of second-generation 5-lipoxygenase inhibitors. These compounds are investigated for their potential therapeutic applications.
Chiral Building Block in Organic Synthesis
As an enantiomerically pure compound, (R)-(+)-3-Butyn-2-ol is a valuable chiral building block. It is used in asymmetric synthesis to introduce specific stereochemistry into target molecules, facilitating the creation of complex organic structures.
Intermediate for Complex Molecules
The presence of both a hydroxyl group and a terminal alkyne makes this compound a versatile intermediate. It can undergo various chemical transformations, enabling its use in the synthesis of a wide range of organic compounds and advanced materials.
| Molecular weight | 70.09 |
|---|---|
| Linear formula | HC≡CCH(OH)CH3 |
| Assay | 98% |
| Boiling point | 108-111 °C(lit.) |
| Density | 0.89 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.426(lit.) |
| Optical activity | [α]22/D +45°, neat |
| Application | Propargylic alcohols are important starting materials for new classes of second generation 5-lipoxygenase inhibitors.1,2 |
Hazard statements
- H226Flammable liquid and vapour
- H300Fatal if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H318Causes serious eye damage
- H330Fatal if inhaled
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 26 °C / 78.8 °F |
| Transport (UN / ADR) | UN 2929 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 10-26/28-36/37/38-40-41-43 |
| Safety statements (S) | 16-24-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(+)-3-Butyn-2-ol used for?
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(R)-(+)-3-Butyn-2-ol is primarily used as a chiral building block in organic synthesis, particularly in the preparation of new classes of 5-lipoxygenase inhibitors and other complex organic molecules where specific stereochemistry is required.
What are the CAS number and chemical formula for (R)-(+)-3-Butyn-2-ol?
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The CAS number for (R)-(+)-3-Butyn-2-ol is 42969-65-3, and its chemical formula is HC≡CCH(OH)CH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(+)-3-Butyn-2-ol with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated otherwise in the product specifications.
What are the main safety hazards associated with (R)-(+)-3-Butyn-2-ol?
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(R)-(+)-3-Butyn-2-ol is classified as a Danger. It is flammable (H226), acutely toxic if swallowed (H300) and inhaled (H330), causes skin irritation (H315), serious eye damage (H318), may cause an allergic skin reaction (H317), respiratory irritation (H335), and is suspected of causing cancer (H351). Always handle with appropriate personal protective equipment in a well-ventilated area.
How is (R)-(+)-3-Butyn-2-ol packaged, shipped, and exported?
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Tech Serve Solutions packages, ships, and exports (R)-(+)-3-Butyn-2-ol in compliance with all relevant international regulations for hazardous materials. Specific packaging details depend on order volume and destination, ensuring safe and secure transit.
How can I request a sample or a quote for (R)-(+)-3-Butyn-2-ol?
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To request a sample or a quote for (R)-(+)-3-Butyn-2-ol, please contact our sales department through the website or by calling us directly. Our team will be happy to assist you with your inquiry.
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