(R)-(−)-2-(Methoxymethyl)pyrrolidine
(R)-(−)-2-(Methoxymethyl)pyrrolidine (CAS: 84025-81-0, Formula: C6H13NO, MW: 115.17) is a valuable chiral building block. As a derivative of proline, it finds significant use in asymmetric synthesis and as a ligand in chiral catalysis. Its specific stereochemistry makes it an important reagent for creating enantiomerically pure compounds in organic chemistry, research, and development.
- IUPAC
- O-Methyl-D-prolinol
- Synonyms
- O-Methyl-D-prolinol
Asymmetric Synthesis
This chiral pyrrolidine derivative serves as a key intermediate and chiral auxiliary in asymmetric synthesis. It enables the stereoselective construction of complex molecules, crucial for pharmaceutical and fine chemical production.
Chiral Ligand Development
The compound's defined stereochemistry makes it suitable for incorporation into chiral ligands. These ligands are vital for developing enantioselective catalysts used in various organic transformations.
Organocatalysis
As a proline-based organocatalyst precursor, (R)-(−)-2-(Methoxymethyl)pyrrolidine can be utilised in catalytic systems that promote stereospecific reactions without the need for metal catalysts.
| Molecular weight | 115.17 |
|---|---|
| Empirical formula | C6H13NO |
| Assay | ≥98.0% (sum of enantiomers, GC) |
| Density | 0.932 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.446 |
| Optical activity | [α]20/D −2.4±0.3°, c = 2% in benzene |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 45 °C / 113 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (R)-(−)-2-(Methoxymethyl)pyrrolidine used for?
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(R)-(−)-2-(Methoxymethyl)pyrrolidine is primarily used in asymmetric synthesis and as a chiral ligand or precursor in organocatalysis due to its specific stereochemistry.
What is the CAS number and formula for (R)-(−)-2-(Methoxymethyl)pyrrolidine?
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The CAS number is 84025-81-0 and the empirical formula is C6H13NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (R)-(−)-2-(Methoxymethyl)pyrrolidine with an assay of ≥98.0% (sum of enantiomers, GC). We do not represent this product as USP, BP, or EP grade.
How should (R)-(−)-2-(Methoxymethyl)pyrrolidine be handled?
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(R)-(−)-2-(Methoxymethyl)pyrrolidine is flammable and can cause skin, eye, and respiratory irritation. Handle with appropriate personal protective equipment, including eyeshields, gloves, and use in a well-ventilated area or with respiratory protection.
Can Tech Serve Solutions export (R)-(−)-2-(Methoxymethyl)pyrrolidine?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, including (R)-(−)-2-(Methoxymethyl)pyrrolidine.
How can I request a quote or sample for (R)-(−)-2-(Methoxymethyl)pyrrolidine?
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Please contact our sales department or use the online enquiry form to request a quote or sample for (R)-(−)-2-(Methoxymethyl)pyrrolidine.
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