Pyridoxal 5′-phosphate monohydrate
Pyridoxal 5′-phosphate monohydrate (CAS: 41468-25-1; Formula: C8H10NO6P · H2O; MW: 265.16) is the active form of Vitamin B6 and a crucial coenzyme. It participates in a wide array of biochemical reactions, including transamination, decarboxylation, and deamination. This compound is vital for numerous metabolic pathways, serving as an enzyme prosthetic group. It is commonly employed in biochemical research and as a reagent in chemical synthesis.
- IUPAC
- 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde,Codecarboxylase,P5P,PLP,Pyridoxal 5-phosphate
- Synonyms
- 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehydeCodecarboxylaseP5PPLPPyridoxal 5-phosphate
Biochemical Research
As the active form of Vitamin B6, Pyridoxal 5′-phosphate monohydrate is extensively used in research to study enzymatic mechanisms, particularly those involving transamination, decarboxylation, and deamination reactions. It serves as a coenzyme in critical metabolic pathways.
Enzyme Cofactor
This compound functions as an essential enzyme prosthetic group, facilitating numerous biochemical transformations. Its role as a coenzyme in reactions such as the conversion of dopa to dopamine and glutamate to GABA highlights its biological significance.
Chemical Synthesis
Pyridoxal 5′-phosphate monohydrate serves as a valuable building block and reagent in organic synthesis. It is utilized in the development of new compounds and in studies involving Schiff-base formation.
Analytical Reagent
It can be employed as a derivatization reagent, particularly in analytical techniques such as HPLC, where it aids in the detection and quantification of specific molecules through fluorescence.
| Molecular weight | 265.16 |
|---|---|
| Empirical formula | C8H10NO6P · H2O |
| Assay | ≥97.0% (NT) |
| Storage temperature | 2-8°C |
| Application | Pyridoxal 5-phosphate (PLP) (active form of Vitamin B6) is an enzyme prosthetic group that acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into GABA; of histidine to histamine. PLP works mechanistically through formation of a Schiff-base. |
| Melting point | 140-143 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Cation traces | Ca: ≤20 mg/kgCd: ≤5 mg/kgCo: ≤5 mg/kgCr: ≤5 mg/kgCu: ≤5 mg/kgFe: ≤50 mg/kgK: ≤50 mg/kgMg: ≤5 mg/kgMn: ≤5 mg/kgNa: ≤2000 mg/kgNi: ≤5 mg/kgPb: ≤5 mg/kgZn: ≤5 mg/kg |
| Anion traces | chloride (Cl-): ≤500 mg/kgsulfate (SO42-): ≤50 mg/kg |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Pyridoxal 5′-phosphate monohydrate used for?
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Pyridoxal 5′-phosphate monohydrate (PLP) is the active form of Vitamin B6 and acts as a crucial coenzyme in numerous biochemical reactions, including transamination, decarboxylation, and deamination. It is vital for studying enzymatic mechanisms and metabolic pathways, and serves as a reagent in chemical synthesis and analytical derivatization.
What is the CAS number and formula for Pyridoxal 5′-phosphate monohydrate?
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The CAS number is 41468-25-1, and the empirical formula is C8H10NO6P · H2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Pyridoxal 5′-phosphate monohydrate with an assay of ≥97.0% (NT). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Pyridoxal 5′-phosphate monohydrate be handled and stored?
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Handle Pyridoxal 5′-phosphate monohydrate with appropriate personal protective equipment, including eyeshields, gloves, and a respirator filter (type N95 or P1). Store the chemical at refrigeration temperatures between 2-8°C.
How is this chemical packed, shipped, and exported?
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Pyridoxal 5′-phosphate monohydrate is carefully packed to maintain its stability during transit. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, adhering to international shipping regulations.
How can I request a sample or quote for Pyridoxal 5′-phosphate monohydrate?
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To request a sample or obtain a quotation for Pyridoxal 5′-phosphate monohydrate, please contact our sales team through the website or by phone.
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