PQ401
PQ401 (CAS 196868-63-0), with the empirical formula C18H16ClN3O2 and a molecular weight of 341.79 g/mol, is a bioactive small molecule. Primarily utilised in cell biology and cell signalling research, it acts as an inhibitor targeting Insulin-Like Growth Factor Receptors (IGF1R and IGf2R). This compound is also relevant in studies of receptor tyrosine kinase biology and inhibitors, contributing to advancements in understanding cellular pathways.
- IUPAC
- IGF-1R Inhibitor II,N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea
- Synonyms
- N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea
IGF-1R Inhibition Studies
PQ401 serves as a potent inhibitor of Insulin-Like Growth Factor Receptors (IGF1R and IGf2R). It is valuable for researchers investigating the role of these receptors in cellular growth, differentiation, and survival.
Cell Signaling Research
This compound is employed to explore signalling pathways mediated by IGF receptors. Its use aids in elucidating complex cellular communication networks, particularly those involving kinase and phosphatase activity.
Receptor Tyrosine Kinase Biology
PQ401 is relevant for studying the biology of receptor tyrosine kinases (RTKs). It can be used as a tool compound to understand the function and inhibition of RTKs in various biological contexts.
| Molecular weight | 341.79 |
|---|---|
| Empirical formula | C18H16ClN3O2 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white |
| Solubility | DMSO: >10 mg/mLH2O: <2 mg/mL |
| Storage temperature | 2-8°C |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is PQ401 used for?
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PQ401 is used in research for its inhibitory effects on Insulin-Like Growth Factor Receptors (IGF1R and IGf2R), and for studies in cell signaling and receptor tyrosine kinase biology.
What is the CAS number and formula for PQ401?
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The CAS number for PQ401 is 196868-63-0, and its empirical formula is C18H16ClN3O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies PQ401 with a purity of ≥98% as determined by HPLC. This product is intended for research purposes and is not supplied as USP, BP, EP, nutraceutical, or food grade.
How should PQ401 be handled safely?
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PQ401 is classified with a Danger signal word due to H301 (Toxic if swallowed). Handling requires appropriate personal protective equipment, including eyeshields, face shields, gloves, and a P2 respirator. Store at 2-8°C. Refer to the Safety Data Sheet for full handling instructions.
How is PQ401 packed and exported?
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PQ401 is supplied as a white powder. As a global supplier, Tech Serve Solutions professionally packs and exports chemicals worldwide in compliance with international shipping regulations, including UN 2811 for transport.
How can I request a quote or sample for PQ401?
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To request a quote or sample for PQ401, please contact our sales team through the website or by phone, providing your contact details and the quantity required.
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