PS-1145 dihydrochloride
PS-1145 dihydrochloride (CAS: 431898-65-6 free base) is a potent I Kappa B Kinase (IKK) inhibitor. With the molecular formula C17H11ClN4O · 2HCl and a molecular weight of 395.67 g/mol, this yellow solid compound is valuable in research settings. It plays a critical role in cell signaling pathways, particularly those involving inflammation and immune responses, making it a key reagent for cell biology and kinase research.
- IUPAC
- N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
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IKK Inhibition Studies
PS-1145 dihydrochloride acts as a selective inhibitor of I Kappa B Kinase (IKK) complexes. This makes it an essential tool for researchers investigating the NF-κB signaling pathway, crucial for understanding inflammatory and immune responses.
Cell Signaling Research
This compound is utilized to probe serine/threonine kinase biology, specifically focusing on pathways regulated by IKK. Its application aids in dissecting cellular responses to various stimuli and in disease model investigations.
Neuroscience Investigations
Given its role in cell signaling, PS-1145 dihydrochloride is employed in neuroscience research to explore its effects on neuronal pathways and associated cellular processes that may be influenced by kinase activity.
| Molecular weight | 395.67 |
|---|---|
| Empirical formula | C17H11ClN4O · 2HCl |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | yellow |
| Solubility | DMSO: >3 mg/mL at ~60 °C, clear (with warming for 2 minutes)methanol: water (1:1): ≥5 mg/mL at 60 °C (With warming for 5 minutes.) |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is PS-1145 dihydrochloride used for?
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PS-1145 dihydrochloride is primarily used as a research tool to inhibit I Kappa B Kinase (IKK) and study the NF-κB signaling pathway, crucial for cell signaling, inflammation, immune responses, and in neuroscience research.
What are the CAS number and formula for PS-1145 dihydrochloride?
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The CAS number for the free base is 431898-65-6. The empirical formula is C17H11ClN4O · 2HCl.
What grade and purity does Tech Serve Solutions supply for PS-1145 dihydrochloride?
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Tech Serve Solutions supplies PS-1145 dihydrochloride with an assay of ≥98% (HPLC). TSS does not represent this compound as USP, BP, or EP grade.
What are the safety and handling recommendations for PS-1145 dihydrochloride?
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PS-1145 dihydrochloride is classified with GHS07 symbol and a 'Warning' signal word, carrying the hazard statement H302 (Harmful if swallowed). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. WGK Germany classification is 3.
How is PS-1145 dihydrochloride shipped and exported?
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PS-1145 dihydrochloride is typically stored at 2-8°C. Tech Serve Solutions is a specialist global supplier and exporter, equipped to handle the packaging and export requirements for this chemical.
How can I request a quote or sample for PS-1145 dihydrochloride?
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To request a quote or sample for PS-1145 dihydrochloride, please contact the Tech Serve Solutions sales team through our website or by phone.
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