Pivaloyl chloride
Pivaloyl chloride, CAS 3282-30-2, with the linear formula (CH₃)₃CCOCl and a molecular weight of 120.58 g/mol, is a key acylating agent in organic synthesis. This acid halide is a colourless liquid, highly reactive, and primarily employed as a building block in the chemical industry for the introduction of the pivaloyl group into various molecules. Its utility spans the synthesis of pharmaceuticals, agrochemicals, and other complex organic compounds.
- IUPAC
- Trimethylacetyl chloride
- Synonyms
- Trimethylacetyl chloride
Acylating Agent
Pivaloyl chloride serves as a versatile reagent for introducing the tert-butylcarbonyl (pivaloyl) group into alcohols, amines, and other nucleophiles. This transformation is critical in modifying molecular structures for desired properties.
Pharmaceutical Intermediate Synthesis
It is extensively used in the multi-step synthesis of active pharmaceutical ingredients (APIs). The pivaloyl group can act as a protecting group or be an integral part of the final drug molecule's structure.
Agrochemical Development
In the agrochemical sector, pivaloyl chloride is utilised in the synthesis of pesticides, herbicides, and fungicides, contributing to the development of crop protection agents.
Organic Building Block
As a fundamental organic building block, it facilitates the construction of complex molecular architectures required for advanced materials and specialty chemicals.
| Molecular weight | 120.58 |
|---|---|
| Linear formula | (CH3)3CCOCl |
| Assay | ≥98.0% (GC) |
| Boiling point | 105-106 °C(lit.) |
| Density | 0.980 g/mL at 20 °C0.979 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.412(lit.)n20/D 1.412 |
| Vapour pressure | 36 mmHg (20 °C) |
| Vapour density | >1 (vs air) |
Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H330Fatal if inhaled
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 19 °C / 66.2 °F |
| Transport (UN / ADR) | UN 2438 6.1/PG 1 |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | F,T+ |
| Risk statements (R) | 11-14-22-26-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Pivaloyl chloride used for?
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Pivaloyl chloride is primarily used as an acylating agent in organic synthesis, serving as a key building block for pharmaceuticals, agrochemicals, and other complex organic compounds by introducing the pivaloyl group.
What is the CAS number and chemical formula for Pivaloyl chloride?
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The CAS number for Pivaloyl chloride is 3282-30-2, and its linear formula is (CH₃)₃CCOCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Pivaloyl chloride with a minimum purity of 98.0% (GC). We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Pivaloyl chloride be handled safely?
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Pivaloyl chloride is a highly flammable liquid and vapour (H225) and is harmful if swallowed (H302). It causes severe skin burns and eye damage (H314) and is fatal if inhaled (H330). It reacts violently with water. Appropriate personal protective equipment, including full-face respirators, chemical-resistant gloves, and eye protection, must be used. Handle in a well-ventilated area or fume hood, away from ignition sources and water.
How is Pivaloyl chloride packed and exported?
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Pivaloyl chloride is expertly packed according to international shipping regulations and exported globally by Tech Serve Solutions to meet the diverse needs of research institutions and industrial clients.
How can I request a quote or sample of Pivaloyl chloride?
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To request a quote or a sample of Pivaloyl chloride, please visit the Tech Serve Solutions website or contact our sales department directly with your inquiry.
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