Piperonylonitrile
Piperonylonitrile (CAS 4421-09-4, C8H5NO2) is a valuable organic compound with a molecular weight of 147.13 g/mol. As a key building block in chemical synthesis, it features a nitrile group attached to a methylenedioxybenzene ring. Piperonylonitrile is primarily utilized in research and development settings for the synthesis of more complex molecules, including its notable use in studies altering the growth of specific bacterial strains.
- IUPAC
- 3,4-(Methylenedioxy)benzonitrile
- Synonyms
- 3,4-(Methylenedioxy)benzonitrile

Chemical Synthesis
Serves as an intermediate and building block in organic synthesis for the creation of novel compounds. Its structure lends itself to various chemical transformations.
Research and Development
Used in laboratory settings for exploring new chemical pathways and developing novel materials. It has been documented for its application in altering bacterial growth patterns.
Nitrogen Compound Intermediate
As a nitrile, it is a useful precursor for introducing nitrogen-containing functionalities into organic molecules.
| Molecular weight | 147.13 |
|---|---|
| Empirical formula | C8H5NO2 |
| Assay | 97% |
| Application | Piperonylonitrile has been used to alter the growth of Nif + and Nif - strains of K.pneumoniae1. |
| Melting point | 91-93 °C(lit.) |

Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Piperonylonitrile used for?
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Piperonylonitrile is primarily used as a building block in chemical synthesis and in research and development. It has also been utilised in studies involving the alteration of bacterial growth, specifically with Nif+ and Nif- strains of K. pneumoniae.
What are the CAS number and formula for Piperonylonitrile?
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The CAS number for Piperonylonitrile is 4421-09-4, and its empirical formula (Hill notation) is C8H5NO2.
What grade and purity does Tech Serve Solutions supply for Piperonylonitrile?
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Tech Serve Solutions supplies Piperonylonitrile with an assay of 97%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should Piperonylonitrile be handled safely?
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Piperonylonitrile is classified as harmful if swallowed, harmful in contact with skin, and harmful if inhaled. Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be worn. Handle in a well-ventilated area.
Is Piperonylonitrile a controlled substance?
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The provided data does not indicate that Piperonylonitrile is a controlled substance.
How is Piperonylonitrile packed and exported by TSS?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals. Specific packaging details for Piperonylonitrile are available upon request, and we comply with all relevant export regulations.
How can I request a quote or sample for Piperonylonitrile?
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To request a quote or sample for Piperonylonitrile, please contact our sales team via the website or direct inquiry channels.
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