Phthalylglycyl chloride
Phthalylglycyl chloride (CAS 6780-38-7) is an organic acid halide with the molecular formula C10H6ClNO3 and a molecular weight of 223.61 g/mol. This compound serves as a valuable reactant in various organic synthesis pathways. Its applications include the preparation of selenium-containing amino acid analogs, cyclic peptides, and functionalised benzofuran derivatives, making it a key intermediate for researchers in medicinal chemistry and organic synthesis.
- IUPAC
- 1,3-Dioxo-2-isoindolineacetyl chloride,NSC 401729,Phthalylglycine acid chloride
- Synonyms
- 1,3-Dioxo-2-isoindolineacetyl chloridePhthalylglycine acid chloride
Synthesis of Selenium-Containing Amino Acid Analogs
Phthalylglycyl chloride is employed as a reactant in the synthesis of novel selenium-containing amino acid analogs, which have demonstrated potential bactericidal and antifungal activities.
Preparation of Cyclic Peptides
This compound facilitates the photoinduced single electron transfer cyclization process, enabling the efficient preparation of cyclic peptides for various research applications.
Arndt-Eistert Synthesis
Phthalylglycyl chloride is a useful reagent in the Arndt-Eistert synthesis, a method for homologising carboxylic acids.
Amido-alkylation Reactions
It participates in amido-alkylation reactions, a key step in the synthesis of diverse benzofuran derivatives.
| Molecular weight | 223.61 |
|---|---|
| Empirical formula | C10H6ClNO3 |
| Assay | 96% |
| Application | Reactant involved in:• Synthesis of selenium-containing amino acid analogs with bactericidal and antifungal activity1• Photoinduced single electron transfer cyclization for preparation of cyclic peptides2• Arndt-Eistert synthesis3• Mitsunobu and arbuzov-type multicomponent pathway4• Remote C-H bond functionalization5• Amido-alkylation for synthesis of benzofuran derivatives6 |
Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2923 8/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phthalylglycyl chloride used for?
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Phthalylglycyl chloride is primarily used as a reactant in organic synthesis, including the preparation of selenium-containing amino acid analogs, cyclic peptides, and benzofuran derivatives. It is also employed in the Arndt-Eistert synthesis.
What is the CAS number and molecular formula for Phthalylglycyl chloride?
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The CAS number for Phthalylglycyl chloride is 6780-38-7, and its empirical formula (Hill notation) is C10H6ClNO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Phthalylglycyl chloride with an assay of 96%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Phthalylglycyl chloride be handled safely?
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Phthalylglycyl chloride is a hazardous substance (Danger, H301-H314). It requires careful handling with appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection. Always consult the Safety Data Sheet before use.
Is Phthalylglycyl chloride a controlled substance?
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The provided data does not indicate that Phthalylglycyl chloride is a controlled substance.
How is Phthalylglycyl chloride shipped and exported?
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Phthalylglycyl chloride is classified under UN 2923, 8/PG 3 for transport. Tech Serve Solutions, as a global supplier and exporter, can facilitate its shipment and export according to relevant regulations.
How can I request a sample or quote for Phthalylglycyl chloride?
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To request a sample or a quote for Phthalylglycyl chloride, please contact our sales team through the website or by phone, referencing the product name and CAS number (6780-38-7).
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