Phenoxybenzamine hydrochloride

CAS 63-92-3C18H22ClNO · HClBiochemicals & Reagents

Phenoxybenzamine hydrochloride (CAS 63-92-3) is a white powder with a molecular weight of 340.29 g/mol. This alpha-adrenergic antagonist functions as a non-selective, long-acting blocker of both alpha-1 and alpha-2 adrenergic receptors. It is employed in scientific research, particularly in studies involving adrenergic signaling, cardiovascular physiology, and neurotransmission. Its properties make it a valuable tool for investigating the roles of adrenergic receptors in various biological systems.

IUPAC: N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride
Synonyms: N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride

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Phenoxybenzamine hydrochloride (C18H22ClNO · HCl) — chemical structure, CAS 63-92-3; Life Science, fine chemical supplied by Tech Serve Solutions

AdrenergicsAdrenergics - AntagonistsAntagonistsBioactive Small MoleculesBiochemicals and ReagentsCell BiologyGPCR ModulatorsGPCR ProteinsModulators and AntibodiesNeuroscience

01 /Applications

Adrenergic Receptor Research

Phenoxybenzamine hydrochloride serves as a critical research tool for studying alpha-adrenergic receptors. Its non-selective, long-acting blockade allows scientists to investigate the physiological effects mediated by these receptors in various experimental models.

Cardiovascular Physiology Studies

Researchers utilise this compound to explore the role of adrenergic signalling in regulating blood pressure, vascular tone, and other cardiovascular functions. Its ability to block alpha-adrenergic receptors provides insights into haemodynamics and related pathologies.

Neuroscience and Neurotransmission Research

As a tool for understanding neurotransmitter systems, phenoxybenzamine hydrochloride can be used to investigate the influence of adrenergic pathways on neuronal activity and signalling within the central and peripheral nervous systems.

Pharmacological Tool

This chemical is utilised in pharmacology to elucidate drug mechanisms of action and to study the complex interactions within the adrenergic system. It helps in understanding the downstream effects of alpha-receptor blockade.

02 /Properties

Molecular weight	340.29
Empirical formula	C18H22ClNO · HCl
Assay	≥97%
Form	powder
Colour	white
Solubility	H2O: slightly solublealcohol: solublepropylene glycol: soluble
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Warning

Hazard statements

H302Harmful if swallowed
H351Suspected of causing cancer

Precautionary statements

P281Use personal protective equipment as required

Protective equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22-40
Safety statements (S)	22-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

63-92-3

MDL number

MFCD00055152

05 /Additional specifications

Gene Information	human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Phenoxybenzamine hydrochloride used for?

Phenoxybenzamine hydrochloride is primarily used as a research chemical for studying alpha-adrenergic receptor function, cardiovascular physiology, and neuroscience.

What is the CAS number and molecular formula?

The CAS number is 63-92-3. The empirical formula is C18H22ClNO · HCl, and the molecular weight is 340.29 g/mol.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Phenoxybenzamine hydrochloride with an assay of ≥97%. We do not represent this product as USP, BP, or EP grade.

What are the key safety considerations for handling Phenoxybenzamine hydrochloride?

Phenoxybenzamine hydrochloride is classified with GHS07 and GHS08 symbols and carries a 'Warning' signal word. It has hazard statements H302 (Harmful if swallowed) and H351 (Suspected of causing cancer). Handle with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (type N100 US or P3 EN143 recommended). Avoid breathing dust. Ensure adequate ventilation and follow specific handling instructions.

How is Phenoxybenzamine hydrochloride packed and shipped?

Phenoxybenzamine hydrochloride is supplied as a white powder and stored at 2-8°C. TSS can export this chemical globally. Please contact us for specific packaging and shipping details relevant to your region.

How can I request a sample or quote for Phenoxybenzamine hydrochloride?

To request a sample or a quote for Phenoxybenzamine hydrochloride, please use the 'Contact Us' form on our website or contact our sales team directly, providing your required quantity and shipping details.