Phentolamine methanesulfonate salt
Phentolamine mesylate (CAS: 65-28-1), a non-selective alpha-adrenergic antagonist, is supplied by TSS as a white to off-white powder. With a molecular weight of 377.46 and a linear formula of C17H19N3O · CH3SO3H, this compound is primarily utilised in research settings for its vasodilatory and anti-hypertensive properties. It is an important tool in pharmacological research, particularly for studying adrenergic receptor activity and its downstream effects in biological systems.
- IUPAC
- 2-(N-[m-Hydroxyphenyl]-p-toluidinomethyl)imidazoline
Pharmacological Research
Phentolamine mesylate serves as a critical research chemical for investigating alpha-adrenergic receptor blockade. Its well-defined antagonist activity allows researchers to explore the physiological roles of alpha-adrenergic signaling pathways in various experimental models.
Cardiovascular Studies
This compound is employed in studies related to cardiovascular function, particularly in understanding the effects of alpha-adrenergic stimulation and blockade on blood pressure and vascular tone. Its vasodilatory effects are a key area of investigation.
Neuroscience Research
Utilised in neuroscience, phentolamine mesylate aids in the study of neurotransmission and receptor function within the central and peripheral nervous systems, specifically concerning adrenergic signaling.
| Molecular weight | 377.46 |
|---|---|
| Linear formula | C17H19N3O · CH3SO3H |
| Assay | ≥98% (TLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | ethanol: soluble26 mg/mLH2O: soluble50 mg/mL |
| Melting point | 180-182 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phentolamine mesylate used for?
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Phentolamine mesylate is primarily used as a research chemical for investigating alpha-adrenergic receptor blockade, cardiovascular function studies, and neuroscience research related to adrenergic signaling.
What is the CAS number and formula for Phentolamine mesylate?
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The CAS number is 65-28-1, and the linear formula is C17H19N3O · CH3SO3H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Phentolamine mesylate with an assay of ≥98% (TLC). This product is intended for laboratory and research use and is not supplied as USP, BP, or EP grade.
How should Phentolamine mesylate be handled?
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Handle Phentolamine mesylate with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. It is harmful if swallowed, in contact with skin, or if inhaled, and causes skin irritation, serious eye irritation, and respiratory irritation.
Is Phentolamine mesylate a controlled substance?
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The provided data does not indicate that Phentolamine mesylate is a controlled substance.
How is Phentolamine mesylate packed and shipped?
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Phentolamine mesylate is supplied as a powder. Specific packaging and shipping details for export are available upon request.
How can I request a sample or quote for Phentolamine mesylate?
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Please contact our sales team via the website to request a sample or a quote for Phentolamine mesylate.
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