Pentafluoropropionic acid
Pentafluoropropionic acid (CAS: 422-64-0), with the molecular formula CF<sub>3</sub>CF<sub>2</sub>COOH and a molecular weight of 164.03 g/mol, is a highly fluorinated carboxylic acid. It is recognised for its utility as a building block in organic synthesis. This compound is employed in analytical techniques, such as its use in the chromatographic analysis of gentamicin. Available from Tech Serve Solutions with an assay of 97%, it serves as a valuable reagent in chemical research and development.
- IUPAC
- Perfluoropropionic acid
- Synonyms
- Perfluoropropionic acid

Analytical Chemistry Reagent
Pentafluoropropionic acid has been utilised in analytical methodologies, specifically in the chromatographic separation and analysis of compounds like gentamicin when employing a Gemini column.
Fluorinated Organic Synthesis
As a fluorinated building block, this compound is integral to the synthesis of more complex fluorinated organic molecules. Its structure allows for the introduction of perfluorinated moieties in various chemical structures.
Research and Development
This carboxylic acid serves as a reagent in laboratory settings for research and development purposes, enabling the exploration of new chemical reactions and the creation of novel compounds.
| Molecular weight | 164.03 |
|---|---|
| Linear formula | CF3CF2COOH |
| Assay | 97% |
| Boiling point | 96-97 °C(lit.) |
| Density | 1.561 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.284(lit.) |
| Vapour pressure | ~40 mmHg (20 °C) |
| Vapour density | ~5.6 (vs air) |
| Application | Pentafluoropropionic acid (Perfluoropropionic acid) was used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods1. |


Hazard statements
- H314Causes severe skin burns and eye damage
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 20-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Pentafluoropropionic acid used for?
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Pentafluoropropionic acid is used as an analytical reagent, for example, in the chromatographic analysis of gentamicin. It also serves as a fluorinated building block in organic synthesis and for general research and development purposes.
What is the CAS number and formula for Pentafluoropropionic acid?
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The CAS number is 422-64-0 and the linear formula is CF<sub>3</sub>CF<sub>2</sub>COOH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Pentafluoropropionic acid with a purity of 97% assay. This is a technical/research grade material and is not represented as USP, BP, or EP grade.
How should Pentafluoropropionic acid be handled safely?
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Pentafluoropropionic acid is classified as Dangerous and causes severe skin burns and eye damage (H314) and is harmful if inhaled (H332). It requires stringent safety precautions, including the use of full-face respirators, chemical-resistant gloves, and eye protection. Always consult the Safety Data Sheet (SDS) before handling.
Is Pentafluoropropionic acid a controlled substance?
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The provided data does not indicate that Pentafluoropropionic acid is a controlled substance.
How is Pentafluoropropionic acid packed, shipped, and exported?
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Pentafluoropropionic acid is shipped as UN 3265, Class 8, Packing Group II, indicating it is a corrosive material. Tech Serve Solutions, as a global supplier, manages the export of chemicals in compliance with international shipping regulations.
How can I request a sample or a quote for Pentafluoropropionic acid?
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To request a sample or a quote, please contact our sales department via the website or directly by phone, providing the product name and CAS number (422-64-0).
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