Pentafluorophenyl trifluoroacetate
Pentafluorophenyl trifluoroacetate (CAS: 14533-84-7, Formula: CF3CO2C6F5) is a fluorinated ester with a molecular weight of 280.07 g/mol. It serves as a valuable reagent in organic synthesis, particularly in chemical biology and peptide chemistry. This compound is recognised for its utility as an active ester and coupling agent in the formation of amide bonds and other esterification reactions, contributing to the development of complex molecules.
- IUPAC
- Trifluoroacetic acid pentafluorophenyl ester
Peptide Synthesis
Pentafluorophenyl trifluoroacetate acts as an efficient activating agent for carboxylic acids in peptide coupling reactions. It facilitates the formation of peptide bonds, crucial for synthesising peptides and peptidomimetics in research and development.
Organic Synthesis Reagent
This compound is employed as a versatile synthetic reagent for esterification and acylation reactions. Its electrophilic nature makes it suitable for introducing trifluoroacetyl groups or activating carboxylic acids for subsequent nucleophilic attack.
Chemical Biology Tool
In chemical biology, pentafluorophenyl trifluoroacetate can be used to modify biomolecules or as a building block in the synthesis of biologically active compounds. Its fluorinated structure can impart unique properties.
| Molecular weight | 280.07 |
|---|---|
| Linear formula | CF3CO2C6F5 |
| Assay | 98% |
| Boiling point | 122-123 °C(lit.) |
| Density | 1.63 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.368(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 52 °C / 125.6 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Pentafluorophenyl trifluoroacetate used for?
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Pentafluorophenyl trifluoroacetate is primarily used as a reagent in organic synthesis, particularly in peptide coupling reactions and as an activating agent for carboxylic acids. It also finds applications in chemical biology and for introducing trifluoroacetyl groups.
What is the CAS number and formula for Pentafluorophenyl trifluoroacetate?
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The CAS number is 14533-84-7 and the chemical formula is CF3CO2C6F5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Pentafluorophenyl trifluoroacetate with a minimum assay of 98%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should Pentafluorophenyl trifluoroacetate be handled safely?
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Pentafluorophenyl trifluoroacetate is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle in a well-ventilated area, away from ignition sources, and wear appropriate personal protective equipment including eyeshields, gloves, and respiratory protection.
Is Pentafluorophenyl trifluoroacetate a controlled substance?
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Based on the provided data, Pentafluorophenyl trifluoroacetate is not listed as a controlled substance.
How is Pentafluorophenyl trifluoroacetate packed and shipped?
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Pentafluorophenyl trifluoroacetate is packed in accordance with relevant dangerous goods regulations (UN 3272 3 / PGIII) for safe transport and is exported globally by Tech Serve Solutions.
How can I request a quote or sample for Pentafluorophenyl trifluoroacetate?
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To request a quote or sample for Pentafluorophenyl trifluoroacetate, please contact the Tech Serve Solutions sales team through our website or by phone.
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