Pentafluorophenyl diphenylphosphinate
Pentafluorophenyl diphenylphosphinate (CAS: 138687-69-1) is an organophosphorus compound with the linear formula (C6H5)2P(O)OC6F5 and a molecular weight of 384.24 g/mol. This compound serves as a valuable building block in organic synthesis. Its utility is demonstrated in catalysing coupling and macrocyclization reactions, as well as in the synthesis of complex molecules such as phorboxazoles and furan-based cyclic homolipeptides.
- IUPAC
- Diphenylphosphinic acid pentafluorophenyl ester
Catalysis in Coupling and Macrocyclization
Pentafluorophenyl diphenylphosphinate acts as a catalyst in various organic transformations, including coupling reactions and the formation of macrocyclic structures. Its involvement facilitates efficient bond formation and ring closure processes.
Reagent in Solid-Phase Synthesis
This compound is employed as a reagent in Fmoc solid-phase peptide synthesis. It aids in the efficient coupling of amino acids or other building blocks onto a solid support, a key step in constructing peptides.
Synthesis of Phorboxazoles
It serves as a key reagent in the synthetic routes leading to phorboxazoles, a class of bioactive natural products. Its specific role facilitates the construction of the core heterocyclic structure.
Preparation of Furan-based Cyclic Homolipeptides
Pentafluorophenyl diphenylphosphinate is utilised in the synthesis of furan-based cyclic homolipeptides. This application highlights its role in constructing complex heterocyclic peptide structures with potential biological relevance.
Synthesis of Ziziphine N
The compound is involved in the synthesis of ziziphine N, a natural product. Its application in this context underscores its versatility in the construction of complex organic molecules.
| Molecular weight | 384.24 |
|---|---|
| Linear formula | (C6H5)2P(O)OC6F5 |
| Application | Catalyst involved in coupling and macrocyclization1Reagent used in: • Fmoc solid-phase synthesis2• Synthesis of phorboxazoles3, furan-based cyclic homoligopeptides4, and ziziphine N5 |
| Melting point | 47-50 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Pentafluorophenyl diphenylphosphinate used for?
+
Pentafluorophenyl diphenylphosphinate is used as a catalyst in coupling and macrocyclization reactions, and as a reagent in Fmoc solid-phase synthesis, the synthesis of phorboxazoles, furan-based cyclic homolipeptides, and ziziphine N.
What is the CAS number and formula for Pentafluorophenyl diphenylphosphinate?
+
The CAS number is 138687-69-1, and the linear formula is (C6H5)2P(O)OC6F5.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies Pentafluorophenyl diphenylphosphinate as a research-grade chemical. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling recommendations for Pentafluorophenyl diphenylphosphinate?
+
For safe handling, wear eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound is classified with WGK Germany of 3, indicating a high hazard to water.
How is Pentafluorophenyl diphenylphosphinate shipped or exported?
+
Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents. Specific shipping and export details for Pentafluorophenyl diphenylphosphinate can be provided upon request.
How can I request a sample or quote for Pentafluorophenyl diphenylphosphinate?
+
To request a sample or a quote for Pentafluorophenyl diphenylphosphinate, please contact our sales team through the website or by phone.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis