Pentafluorophenol
Pentafluorophenol (CAS: 771-61-9, Formula: C6F5OH, MW: 184.06) is a fluorinated aromatic alcohol. This versatile compound serves as a key reagent in organic synthesis, particularly for the preparation of pentafluorophenyl esters. These esters are widely employed as activated intermediates in peptide synthesis and the creation of other complex molecules, making Pentafluorophenol an important building block in chemical research and development.
- IUPAC
- 2,3,4,5,6-Pentafluorophenol
Peptide Synthesis
Pentafluorophenol is used to form pentafluorophenyl esters, which are highly reactive activated intermediates crucial for efficient amide bond formation in peptide synthesis.
Organic Synthesis
It acts as a precursor for a variety of fluorinated organic compounds and is valuable in reactions requiring activated hydroxyl groups for esterification.
Chemical Biology
Utilised in the preparation of reagents for bioconjugation and modifying biomolecules due to the unique properties imparted by the pentafluorophenyl group.
Active Esters and Additives
Serves as a source for active esters, enhancing reactivity in various coupling reactions and syntheses.
| Molecular weight | 184.06 |
|---|---|
| Linear formula | C6F5OH |
| Assay | ≥99% |
| Grade | ReagentPlus® |
| Boiling point | 143 °C(lit.) |
| Application | For the preparation of pentafluorophenyl esters for peptide synthesis. |
| Melting point | 34-36 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 72 °C / 161.6 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Pentafluorophenol used for?
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Pentafluorophenol is primarily used for the preparation of pentafluorophenyl esters, which are activated intermediates valuable in peptide synthesis and other organic coupling reactions.
What are the CAS number and formula for Pentafluorophenol?
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The CAS number for Pentafluorophenol is 771-61-9, and its chemical formula is C6F5OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Pentafluorophenol with a minimum assay of ≥99%, designated as ReagentPlus® grade. We do not represent this product as USP, BP, or EP grade.
How should Pentafluorophenol be handled safely?
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Pentafluorophenol is a warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Always use appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure adequate ventilation.
How is Pentafluorophenol packed, shipped, and exported?
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Tech Serve Solutions professionally packs, ships, and exports Pentafluorophenol adhering to all relevant international regulations for chemical substances.
How can I request a quote or sample of Pentafluorophenol?
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To request a quote or a sample of Pentafluorophenol, please contact our sales team through the website or call us directly.
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