Pentafluorophenyl acetate
Pentafluorophenyl acetate (CAS 19220-93-0), with the chemical formula C8H3F5O2 and a molecular weight of 226.10 g/mol, is a valuable reagent in organic synthesis. It serves as a key intermediate and derivatizing agent, particularly in areas requiring the introduction of the pentafluorophenyl group. Its reactivity makes it useful in the preparation of various fluorinated organic compounds and for modifying functional groups in complex molecules.
- IUPAC
- Acetic acid pentafluorophenyl ester

Protecting Group Chemistry
Pentafluorophenyl acetate can be employed in the protection of sensitive functional groups during multi-step organic syntheses. The pentafluorophenyl ester moiety offers distinct reactivity and cleavage conditions compared to traditional protecting groups.
Derivatization Reagent
It is utilized as a derivatizing agent to enhance the detectability or separability of analytes in analytical chemistry, particularly in chromatography. The introduction of the pentafluorophenyl group can improve volatility or chromatographic behaviour.
Synthesis of Fluorinated Compounds
This compound acts as a building block for the synthesis of more complex fluorinated organic molecules. These fluorinated compounds often find applications in pharmaceuticals, agrochemicals, and materials science.
| Molecular weight | 226.10 |
|---|---|
| Empirical formula | C8H3F5O2 |
| Assay | ≥97.0% (GC) |
| Storage temperature | 2-8°C |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Pentafluorophenyl acetate used for?
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Pentafluorophenyl acetate is primarily used in organic synthesis as a protecting group reagent and for the derivatization of compounds, aiding in their analysis or facilitating the synthesis of fluorinated organic molecules.
What is the CAS number and chemical formula for Pentafluorophenyl acetate?
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The CAS number is 19220-93-0, and the chemical formula is C8H3F5O2.
What grade and purity does Tech Serve Solutions supply for Pentafluorophenyl acetate?
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Tech Serve Solutions supplies Pentafluorophenyl acetate with an assay of ≥97.0% (GC). We do not represent this product as meeting USP, BP, EP, or other pharmacopoeia standards.
How should Pentafluorophenyl acetate be handled and stored?
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Pentafluorophenyl acetate is classified as an irritant to the skin, eyes, and respiratory tract. Handle with appropriate personal protective equipment, ensuring adequate ventilation, and store at 2-8°C to maintain stability.
Is Pentafluorophenyl acetate a controlled substance?
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Based on the provided data, Pentafluorophenyl acetate is not indicated as a controlled substance.
How is Pentafluorophenyl acetate shipped and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter of fine chemicals since 1998, is experienced in shipping and exporting Pentafluorophenyl acetate in compliance with international regulations.
How can I request a quote or sample of Pentafluorophenyl acetate?
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To request a quote or sample of Pentafluorophenyl acetate, please contact our sales team through the provided channels on the Tech Serve Solutions website.
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