Pentafluorobenzenesulfonyl chloride
Pentafluorobenzenesulfonyl chloride (CAS: 832-53-1), with the molecular formula C6F5SO2Cl and a molar mass of 266.57 g/mol, is a key fluorinated building block. It is primarily utilised in organic synthesis as a derivatising agent for analytical purposes. Its reactivity makes it valuable for labelling peptides and determining specific compounds in complex biological matrices.
Derivatising Reagent in Analytical Chemistry
Pentafluorobenzenesulfonyl chloride serves as a derivatising reagent for the simultaneous determination of compounds such as fluoxetine and its metabolites in human liver microsomes. This application leverages its ability to form stable derivatives suitable for chromatographic analysis.
Electrophore Labelling for GC-ECD Analysis
This compound is employed for electrophore labelling of small tyrosyl peptides. The resulting derivatives can be effectively analysed using gas chromatography with electron-capture detection, facilitating sensitive detection of these biomolecules.
Organic Synthesis Intermediate
As a fluorinated building block, Pentafluorobenzenesulfonyl chloride is a versatile intermediate in the synthesis of various organic molecules. Its pentafluorophenylsulfonyl group offers unique electronic and steric properties for designing novel compounds.
| Molecular weight | 266.57 |
|---|---|
| Linear formula | C6F5SO2Cl |
| Assay | 99% |
| Boiling point | 210-211 °C(lit.) |
| Density | 1.796 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.479(lit.) |
| Application | Pentafluorobenzenesulfonyl chloride was used as derivatizing reagent for simultaneous determination of fluoxetine and p-trifluoromethylphenol, an O-dealkylated metabolite of fluoxetine in human liver microsomes1. Pentafluorobenzenesulfonyl chloride was used for electrophore labeling of small tyrosyl peptides for their analysis by gas chromatography with electron-capture detection2. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 90 °C / 194 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Pentafluorobenzenesulfonyl chloride used for?
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Pentafluorobenzenesulfonyl chloride is used as a derivatising reagent in analytical chemistry, for electrophore labelling of peptides, and as a building block in organic synthesis.
What are the CAS number and formula for Pentafluorobenzenesulfonyl chloride?
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The CAS number is 832-53-1 and the molecular formula is C6F5SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Pentafluorobenzenesulfonyl chloride with a minimum assay of 99%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should Pentafluorobenzenesulfonyl chloride be handled safely?
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Pentafluorobenzenesulfonyl chloride is classified as corrosive and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including eyeshields, face shields, and gloves, in a well-ventilated area. Consult the Safety Data Sheet for detailed handling procedures.
Is Pentafluorobenzenesulfonyl chloride available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Pentafluorobenzenesulfonyl chloride.
How can I request a sample or quote for Pentafluorobenzenesulfonyl chloride?
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To request a sample or quote, please contact our sales team through the website or by phone, providing the product name and CAS number.
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