O-(Trimethylsilyl)hydroxylamine
O-(Trimethylsilyl)hydroxylamine (CAS 22737-36-6) is a chemical compound with the linear formula (CH3)3SiONH2 and a molecular weight of 105.21 g/mol. This organic building block, identified by MDL number MFCD00010872, is primarily utilised in chemical synthesis. Its properties make it a valuable reagent for introducing the aminoxy group in organic chemistry research and development.
- IUPAC
- Aminoxytrimethylsilane
- Synonyms
- Aminoxytrimethylsilane

Organic Synthesis Reagent
O-(Trimethylsilyl)hydroxylamine serves as a versatile building block in organic synthesis. It is employed to introduce the trimethylsilyloxyamine functionality into various organic molecules.
Intermediate in Chemical Research
This compound is valuable for researchers exploring new synthetic pathways. It facilitates the formation of specific bonds and functional groups essential for developing novel chemical entities.
Precursor for Nitrogen-Containing Compounds
Its structure allows for its use as a precursor in the synthesis of diverse nitrogen-containing organic compounds, which are important in pharmaceuticals and material science.
| Molecular weight | 105.21 |
|---|---|
| Linear formula | (CH3)3SiONH2 |
| Assay | ≥90% (GC) |
| Boiling point | 98-100 °C(lit.) |
| Density | 0.86 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.405(lit.)n20/D 1.405 |
| Storage temperature | 2-8°C |
| Impurities tested | hexamethyl siloxane |


Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 12 °C / 53.6 °F |
| Transport (UN / ADR) | UN 2733 3/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-(Trimethylsilyl)hydroxylamine used for?
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O-(Trimethylsilyl)hydroxylamine (CAS 22737-36-6) is primarily used as a building block and reagent in organic synthesis and chemical research for introducing the aminoxy group.
What is the CAS number and formula for O-(Trimethylsilyl)hydroxylamine?
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The CAS number is 22737-36-6, and the linear formula is (CH3)3SiONH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies O-(Trimethylsilyl)hydroxylamine with an assay of ≥90% (GC). This compound is not supplied as USP, BP, or EP grade.
How should O-(Trimethylsilyl)hydroxylamine be handled safely?
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O-(Trimethylsilyl)hydroxylamine is a flammable liquid and causes severe skin burns and eye damage (H225-H314). Handle with appropriate personal protective equipment, including gloves, goggles, and face shields, in a well-ventilated area, and avoid ignition sources. Refer to the Safety Data Sheet for detailed handling procedures.
Is O-(Trimethylsilyl)hydroxylamine a controlled substance?
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The provided data does not indicate that O-(Trimethylsilyl)hydroxylamine is a controlled substance.
How is O-(Trimethylsilyl)hydroxylamine packed, shipped, and exported?
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O-(Trimethylsilyl)hydroxylamine is packed according to relevant transportation regulations for hazardous materials. Tech Serve Solutions is experienced in global export of chemicals.
How can I request a sample or quote for O-(Trimethylsilyl)hydroxylamine?
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Please contact our sales team directly through the website to request a sample or a formal quotation for O-(Trimethylsilyl)hydroxylamine.
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