O-(tert-Butyldimethylsilyl)hydroxylamine
O-(tert-Butyldimethylsilyl)hydroxylamine (CAS 41879-39-4) is a protected hydroxylamine derivative with the linear formula (CH3)3CSi(CH3)2ONH2 and a molecular weight of 147.29 g/mol. This compound serves as a valuable intermediate and building block in organic synthesis. It is frequently employed in reactions requiring a masked hydroxylamine functionality, offering controlled reactivity for the introduction of aminoxy groups into various molecular scaffolds.
- IUPAC
- Aminoxy-tert-butyldimethylsilane

Organic Synthesis Intermediate
Serves as a protected hydroxylamine reagent for introducing aminoxy functionalities into organic molecules. Its silyl protecting group allows for selective reactions and subsequent deprotection under specific conditions.
Pharmaceutical Building Block
Utilised in the synthesis of complex organic molecules, including potential pharmaceutical intermediates. The aminoxy group can be a key feature in the development of new drug candidates.
Reagent in Nitrogen Compound Synthesis
Applied in the construction of diverse nitrogen-containing compounds. Its structure facilitates the incorporation of a nitrogen atom into target molecules for research and development.
| Molecular weight | 147.29 |
|---|---|
| Linear formula | (CH3)3CSi(CH3)2ONH2 |
| Assay | 95% |
| Boiling point | 87-90 °C/40 mmHg(lit.) |
| Melting point | 62-65 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3259PSN1 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-(tert-Butyldimethylsilyl)hydroxylamine used for?
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O-(tert-Butyldimethylsilyl)hydroxylamine is primarily used as a protected hydroxylamine intermediate and building block in organic synthesis, particularly for introducing aminoxy groups into molecules.
What is the CAS number and formula for O-(tert-Butyldimethylsilyl)hydroxylamine?
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The CAS number is 41879-39-4, and its linear formula is (CH3)3CSi(CH3)2ONH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies O-(tert-Butyldimethylsilyl)hydroxylamine with a purity of 95%. This is a technical grade suitable for research and synthesis; TSS does not represent it as USP, BP, or EP grade.
What are the main hazards associated with this chemical?
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This compound is classified with the signal word 'Warning' and carries hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be used.
Is this product available for international export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including O-(tert-Butyldimethylsilyl)hydroxylamine, and can facilitate international shipments.
How can I request a quote or sample?
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To request a quote or a sample, please contact our sales department through the website or by phone, providing the product name and CAS number (41879-39-4).
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