O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (CAS: 125700-67-6) is a uronium salt with the molecular formula C11H16N5O · BF4 and a molecular weight of 321.08. This compound serves as an efficient coupling reagent, particularly well-suited for solid-phase peptide synthesis. Its reliability and effectiveness make it a valuable reagent in chemical synthesis and peptide chemistry laboratories.
- IUPAC
- N,N,N′,N′-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate,TBTU
- Synonyms
- N′-tetramethyluronium tetrafluoroborate125700-67-6C11H16N5O · BF4TBTU

Solid-Phase Peptide Synthesis
This uronium salt is ideally suited for solid-phase peptide synthesis, facilitating the formation of amide bonds between amino acids.
Chemical Synthesis
As a versatile coupling reagent, it is employed in various chemical synthesis applications where amide bond formation is required.
Peptide Chemistry
It is a key reagent in peptide chemistry, aiding in the construction of peptide chains for research and development.
| Molecular weight | 321.08 |
|---|---|
| Linear formula | C11H16N5O · BF4 |
| Assay | 97% |
| Application | Coupling reagent which is ideally suited for solid-phase peptide synthesis. |
| Melting point | 205 °C (dec.)(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate used for?
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O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate is primarily used as a coupling reagent, especially for solid-phase peptide synthesis and other chemical synthesis requiring amide bond formation.
What are the CAS number and formula for this compound?
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The CAS number is 125700-67-6, and the linear formula is C11H16N5O · BF4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 97%. We do not represent it as USP, BP, or EP grade.
How should O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate be handled safely?
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This compound is a Warning substance (GHS07) that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). It should be handled with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, in a well-ventilated area.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports fine chemicals globally, adhering to all necessary regulations for safe transport.
How can I request a sample or quote for this product?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team via our website or direct contact details.
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