O-(6-Chlorobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate
O-(6-Chlorobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (CAS 330645-87-9) is a key reagent with the molecular formula C11H15ClF6N5OP and a molecular weight of 413.69 g/mol. It is primarily utilised in chemical synthesis, particularly for peptide coupling and the creation of complex organic molecules. This compound serves as an efficient coupling agent in various synthetic pathways, contributing to advancements in chemical biology and materials science.
- IUPAC
- 1-[Bis(dimethylamino)methylen]-5-chlorobenzotriazolium 3-oxide hexafluorophosphate,N,N,N′,N′-Tetramethyl-O-(6-chloro-1H-benzotriazol-1-yl)uronium hexafluorophosphate,HCTU
- Synonyms
- N′-tetramethyluronium hexafluorophosphate,330645-87-9, C11H15ClF6N5OP,1-[Bis(dimethylamino)methylen]-5-chlorobenzotriazolium 3-oxide hexafluorophosphate,N,N,N′,N′-Tetramethyl-O-(6-chloro-1H-benzotriazol-1-yl)uronium hexafluorophosphate,HCTU
Peptide Synthesis Reagent
This uronium salt is instrumental in peptide bond formation, facilitating the synthesis of peptide chains. Its effectiveness is crucial for constructing peptides used in research and potentially therapeutic applications.
Fluorescent Probe Synthesis
It serves as a reagent in the synthesis of near-infrared pH-activatable fluorescent probes. These probes are valuable tools in chemical biology for monitoring biological processes.
Organic Synthesis Applications
Beyond peptide chemistry, this compound finds application in various organic syntheses, including stereoselective Horner-Wadsworth-Emmons olefination and the alkylation of specific DNA sequences.
Bioconjugation Chemistry
It is employed in the covalent ligation of fluorescently labelled peptides to nanostructures like quantum dots, enabling advanced bioimaging and diagnostic tools.
| Molecular weight | 413.69 |
|---|---|
| Empirical formula | C11H15ClF6N5OP |
| Assay | ≥98.0% (HPLC) |
| Impurities tested | ≤0.5% water |
| Application | Reagent for: Synthesis of near-infrared pH activatable fluorescent probes1 Synthesis of human β-amyloid by Fmoc chemistry2 Stereoselective Horner-Wadsworth-Emmons olefination3 Covalent ligation of fluorescent peptides to quantum dots4 Alkylation of human telomere sequence5 |
| Melting point | 185-190 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-(6-Chlorobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate used for?
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This compound is a versatile reagent utilised in peptide synthesis, the creation of fluorescent probes, stereoselective olefination, and bioconjugation of peptides to quantum dots.
What are the CAS number and molecular formula for this product?
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The CAS number is 330645-87-9, and the molecular formula is C11H15ClF6N5OP.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥98.0% by HPLC and ≤0.5% water content. It is supplied as a research or technical grade reagent and is not represented as USP, BP, or EP grade.
How should O-(6-Chlorobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate be handled?
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This compound is classified under WGK Germany 3, indicating it is hazardous to water. Appropriate personal protective equipment and handling procedures should be employed to avoid contact and inhalation.
How is this chemical packed and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging and compliance with international shipping regulations for all its chemical products.
How can I request a sample or a quote for this product?
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To request a sample or a quote, please contact our sales team through the designated channels on the Tech Serve Solutions website.
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