2-tert-Butyldimethylsiloxybut-3-yne
2-tert-Butyldimethylsiloxybut-3-yne (CAS: 125494-93-1, C10H20OSi) is a versatile organosilicon compound with a molecular weight of 184.35 g/mol. It serves as a valuable building block in organic synthesis, particularly for creating more complex molecules. This terminal alkyne derivative is often employed in chemical research and development for its unique reactivity and structural properties in constructing carbon frameworks.
- IUPAC
- tert-Butyl-dimethyl-(methyl-prop-2-ynloxy)silane

Organic Synthesis Reagent
This compound is utilized as a key intermediate in multi-step organic syntheses. Its terminal alkyne functionality allows for various coupling reactions and functional group transformations, contributing to the construction of diverse molecular architectures.
Building Block for Complex Molecules
2-tert-Butyldimethylsiloxybut-3-yne is employed in the synthesis of complex organic molecules, including potential pharmaceutical intermediates. Its silyl-protected alkyne moiety offers controlled reactivity for regioselective functionalization.
Research and Development
As a specialized chemical, it is used in academic and industrial research laboratories to explore novel synthetic pathways and develop new chemical entities. Its properties make it suitable for investigations in materials science and medicinal chemistry.
| Molecular weight | 184.35 |
|---|---|
| Empirical formula | C10H20OSi |
| Assay | 97% |
| Boiling point | 40-42 °C/9 mbar |
| Density | 0.812 g/mL at 25 °C |
| Refractive index | n20/D 1.423 |

Hazard statements
- H226Flammable liquid and vapour
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 39 °C / 102.2 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 10 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-tert-Butyldimethylsiloxybut-3-yne used for?
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2-tert-Butyldimethylsiloxybut-3-yne is primarily used as a building block in organic synthesis and for the development of complex molecules in research and development settings.
What is the CAS number and formula for 2-tert-Butyldimethylsiloxybut-3-yne?
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The CAS number is 125494-93-1 and the molecular formula is C10H20OSi.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-tert-Butyldimethylsiloxybut-3-yne with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 2-tert-Butyldimethylsiloxybut-3-yne be handled safely?
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This compound is flammable (H226) and requires careful handling. Use appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Store away from ignition sources in a well-ventilated area.
Is 2-tert-Butyldimethylsiloxybut-3-yne a controlled substance?
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The provided data does not indicate that 2-tert-Butyldimethylsiloxybut-3-yne is a controlled substance.
How is this chemical shipped and exported?
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2-tert-Butyldimethylsiloxybut-3-yne is shipped according to UN 1993 regulations (C3 / PGIII). As a global supplier, Tech Serve Solutions exports this chemical worldwide.
How can I request a sample or a quote for 2-tert-Butyldimethylsiloxybut-3-yne?
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Please contact Tech Serve Solutions directly via our website or phone to request a sample or obtain a quotation for 2-tert-Butyldimethylsiloxybut-3-yne.
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