Nigericin sodium salt
Nigericin sodium salt (CAS: 28643-80-3; C40H67NaO11) is a polyether ionophore antibiotic derived from Streptomyces hygroscopicus. This compound functions by complexing with cations and facilitating their transport across biological membranes, thereby altering membrane potential and permeability. It is primarily recognised for its antibacterial properties and is widely employed as a biochemical reagent in research settings for studying ion transport and cellular processes.
- IUPAC
- Antibiotic K178,Antibiotic X464,Azalomycin M,Helexin C,Polyetherin A
- Synonyms
- Antibiotic K178Antibiotic X464Azalomycin MHelexin CPolyetherin A
Biochemical Research
Nigericin sodium salt is a valuable tool in biochemistry and cell biology laboratories. It is used to investigate ion transport mechanisms, particularly the movement of potassium ions across cellular membranes.
Antibacterial Studies
As an antibiotic, nigericin sodium salt exhibits activity against various bacteria. It is utilised in research to study antibiotic mechanisms of action and to explore potential therapeutic applications.
Ionophore Studies
Its function as a potassium ionophore makes it essential for studies focused on cellular energy production, apoptosis, and signal transduction pathways influenced by ion gradients.
| Molecular weight | 746.94 |
|---|---|
| Empirical formula | C40H67NaO11 |
| Assay | ≥98% (TLC) |
| Solubility | chloroform: soluble10 mg/mL, clear, colorless |
| Storage temperature | 2-8°C |
| Biological source | from Streptomyces hygroscopicus |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Nigericin sodium salt used for?
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Nigericin sodium salt is primarily used in biochemical research to study ion transport, particularly potassium ions, across cell membranes. It also exhibits antibacterial properties and is employed in the study of antibiotic mechanisms.
What is the CAS number and formula for Nigericin sodium salt?
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The CAS number for Nigericin sodium salt is 28643-80-3, and its molecular formula is C40H67NaO11.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Nigericin sodium salt with an assay of ≥98% (TLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the primary safety concerns when handling Nigericin sodium salt?
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Nigericin sodium salt is classified as toxic if swallowed (H301), and causes skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges, must be used. Handle in a well-ventilated area and seek immediate medical attention if exposed.
How is Nigericin sodium salt shipped and exported?
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Nigericin sodium salt is shipped and exported according to strict international regulations for hazardous materials, identified under UN 3462, Hazard Class 6.1, Packing Group III. Tech Serve Solutions ensures compliant packaging and documentation for global distribution.
How can I request a quote or sample of Nigericin sodium salt?
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To request a quote or a sample of Nigericin sodium salt, please contact our sales team via the website or your designated account manager. We are happy to assist with your research needs.
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