N,O-Bis(trimethylsilyl)acetamide
N,O-Bis(trimethylsilyl)acetamide (CAS: 10416-59-8) is an organosilicon compound with the linear formula CH3C[=NSi(CH3)3]OSi(CH3)3 and a molecular weight of 203.43 g/mol. This reagent is primarily utilised as a silylating agent in organic synthesis. It is effective for the protection of hydroxyl and carboxyl groups, and for the derivatisation of compounds for chromatographic analysis. Tech Serve Solutions supplies this chemical for research and development purposes.
- IUPAC
- BSA
- Synonyms
- CH3C[=NSi(CH3)3]OSi(CH3)3BSA
![N,O-Bis(trimethylsilyl)acetamide (CH3C[=NSi(CH3)3]OSi(CH3)3) — chemical structure, CAS 10416-59-8; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F10416-59-8.png&w=3840&q=75)
Silylating Agent
N,O-Bis(trimethylsilyl)acetamide is a potent silylating agent, widely employed for the protection of hydroxyl, carboxyl, and amino functionalities in organic molecules. It reacts readily to form stable silyl ethers and amides, facilitating subsequent transformations.
Derivatisation Reagent
This compound serves as a valuable derivatisation reagent for enhancing the volatility and thermal stability of analytes. This is particularly useful in gas chromatography (GC) and mass spectrometry (MS) analysis of polar compounds.
Organic Synthesis Building Block
As an acyclic alkene derivative and organic building block, it is integrated into various synthetic pathways. Its unique structure allows for specific chemical modifications and the construction of complex organic molecules.
| Molecular weight | 203.43 |
|---|---|
| Linear formula | CH3C[=NSi(CH3)3]OSi(CH3)3 |
| Assay | ≥95.0% (GC) |
| Boiling point | 71-73 °C/35 mmHg(lit.) |
| Density | 0.832 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.417(lit.)n20/D 1.418 |
| Concentration | 5% in TMCS |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 44 °C / 111.2 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-14-22-34 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,O-Bis(trimethylsilyl)acetamide used for?
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N,O-Bis(trimethylsilyl)acetamide is primarily used as a silylating agent for protecting functional groups like hydroxyl and carboxyl, and as a derivatisation reagent for analytical chemistry, particularly in GC and MS.
What is the CAS number and formula for N,O-Bis(trimethylsilyl)acetamide?
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The CAS number is 10416-59-8, and the linear formula is CH3C[=NSi(CH3)3]OSi(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,O-Bis(trimethylsilyl)acetamide with an assay of ≥95.0% (GC). This product is not supplied as USP, BP, EP, or pharmacopoeia grade.
How should N,O-Bis(trimethylsilyl)acetamide be handled safely?
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N,O-Bis(trimethylsilyl)acetamide is a flammable liquid (H226) and is corrosive (H314), causing severe skin burns and eye damage. It is also harmful if swallowed (H302) and reacts violently with water. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, is essential. Ensure adequate ventilation and handle away from ignition sources and moisture.
How is N,O-Bis(trimethylsilyl)acetamide packed and exported?
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Tech Serve Solutions expertly packs and exports N,O-Bis(trimethylsilyl)acetamide, adhering to all relevant transportation regulations for hazardous materials. We cater to global clients, ensuring safe and compliant delivery.
How can I request a sample or quote for N,O-Bis(trimethylsilyl)acetamide?
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To request a sample or a quote, please contact our sales team via the website or call us directly. Provide the product name and CAS number (10416-59-8) for prompt service.
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