N,O-Bis(trimethylsilyl)carbamate
N,O-Bis(trimethylsilyl)carbamate (CAS: 35342-88-2) is a silylation reagent with the linear formula (CH3)3SiNHCO2Si(CH3)3 and a molecular weight of 205.40 g/mol. It serves as a versatile building block in organic synthesis and is particularly useful for derivatization in analytical chemistry, including gas chromatography. This compound is supplied by Tech Serve Solutions for research and industrial applications, offering a reliable option for silylation reactions.
- IUPAC
- BSC,Trimethylsilyl N-(trimethylsilyl)carbamate
- Synonyms
- (CH3)3SiNHCO2Si(CH3)3Trimethylsilyl N-(trimethylsilyl)carbamate

Derivatization Reagent
N,O-Bis(trimethylsilyl)carbamate is employed as a derivatization reagent, particularly for gas chromatography (GC). It reacts with active hydrogen-containing compounds to form volatile derivatives, enhancing their detectability and chromatographic separation.
Silylation Agent
This compound acts as an effective silylation agent, introducing trimethylsilyl (TMS) groups into organic molecules. This process can protect functional groups, increase solubility in organic solvents, or modify the reactivity of the substrate.
Organic Synthesis Building Block
As a building block in chemical synthesis, N,O-Bis(trimethylsilyl)carbamate can be utilized in the preparation of various organic compounds. Its structure allows for incorporation into more complex molecular architectures.
Analytical Chemistry
In analytical chemistry, it is used to prepare samples for analysis. By silylating analytes, their physical properties can be altered to suit specific analytical techniques, improving the accuracy and precision of measurements.
| Molecular weight | 205.40 |
|---|---|
| Linear formula | (CH3)3SiNHCO2Si(CH3)3 |
| Assay | ≥98.0% (T) |
| Melting point | 71-80 °C(lit.)77-80 °C |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,O-Bis(trimethylsilyl)carbamate used for?
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N,O-Bis(trimethylsilyl)carbamate is primarily used as a derivatization reagent in analytical chemistry, particularly for gas chromatography, and as a silylation agent and building block in organic synthesis.
What is the CAS number and formula for N,O-Bis(trimethylsilyl)carbamate?
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The CAS number is 35342-88-2, and the linear formula is (CH3)3SiNHCO2Si(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,O-Bis(trimethylsilyl)carbamate with an assay of ≥98.0% (T). This compound is intended for research and technical use and is not represented as USP, BP, EP, or pharmacopoeia grade.
How should N,O-Bis(trimethylsilyl)carbamate be handled safely?
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N,O-Bis(trimethylsilyl)carbamate is a warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95 US), eyeshields, and gloves, should be worn. Ensure adequate ventilation.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packs and ships N,O-Bis(trimethylsilyl)carbamate adhering to all relevant safety and transport regulations. We are a global supplier and exporter experienced in handling fine chemicals for international delivery.
How can I request a sample or quote for N,O-Bis(trimethylsilyl)carbamate?
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To request a sample or obtain a quote for N,O-Bis(trimethylsilyl)carbamate, please contact our sales team through the website or by phone, providing your contact details and the quantity required.
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