N,N,N′,N′-Tetramethylphosphorodiamidic chloride
N,N,N′,N′-Tetramethylphosphorodiamidic chloride (CAS: 1605-65-8), with the linear formula [(CH3)2N]2P(O)Cl, is a chemical compound with a molecular weight of 170.58 g/mol. It serves as a valuable building block in organic synthesis. This compound has been utilized in the preparation of complex molecules, including natural product analogues and chiral ligands. Its applications primarily lie within research and development settings for chemical synthesis.
- IUPAC
- Bis(dimethylamido)phosphoric chloride
- Synonyms
- N′-Tetramethylphosphorodiamidic chloride[(CH3)2N]2P(O)ClBis(dimethylamido)phosphoric chloride
Synthesis of Natural Product Analogues
N,N,N′,N′-Tetramethylphosphorodiamidic chloride has been employed in the synthesis of natural products and their analogues, such as (-)-allohedycaryol and neohedycaryol. This highlights its utility in complex organic synthesis pathways.
Preparation of Chiral Ligands
The compound has been used in the development of C2-symmetric binaphthyl phosphortriamide, indicating its application in creating chiral auxiliaries or ligands for asymmetric synthesis.
Reagent in Chemical Synthesis
As a phosphorus halide derivative, it functions as a reagent in various organic transformations. Its reactivity makes it useful for introducing specific functional groups in research and development.
| Molecular weight | 170.58 |
|---|---|
| Linear formula | [(CH3)2N]2P(O)Cl |
| Assay | 90% |
| Density | 1.152 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.466(lit.) |
| Application | N,N,N′,N′-Tetramethylphosphorodiamidic chloride was used in the synthesis of (-)-allohedycaryol1 and C2-symmetric binaphthyl phosphortriamide2. It was also used in total synthesis of neohedycaryol3. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N,N′,N′-Tetramethylphosphorodiamidic chloride used for?
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N,N,N′,N′-Tetramethylphosphorodiamidic chloride is used as a building block in organic synthesis, particularly in the preparation of natural product analogues like (-)-allohedycaryol and neohedycaryol, and in the synthesis of chiral ligands such as C2-symmetric binaphthyl phosphortriamide.
What is the CAS number and chemical formula for N,N,N′,N′-Tetramethylphosphorodiamidic chloride?
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The CAS number is 1605-65-8, and the linear formula is [(CH3)2N]2P(O)Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N,N′,N′-Tetramethylphosphorodiamidic chloride with an assay of 90%. This product is intended for research and technical use; TSS does not represent it as USP, BP, or EP grade.
How is N,N,N′,N′-Tetramethylphosphorodiamidic chloride handled and shipped?
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This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including face shields, gloves, and respirators, must be used. It is shipped as UN 3265, Class 8, Packing Group II, reflecting its corrosive nature.
How can I request a quote or sample for N,N,N′,N′-Tetramethylphosphorodiamidic chloride?
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To request a quote or sample, please contact our sales team through the website or by phone. Provide the product name and CAS number (1605-65-8) for prompt service.
Is N,N,N′,N′-Tetramethylphosphorodiamidic chloride a controlled substance?
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The provided safety data does not indicate that N,N,N′,N′-Tetramethylphosphorodiamidic chloride is a controlled substance.
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