N-Boc-cadaverine
N-Boc-cadaverine (CAS: 51644-96-3), chemically known as tert-Butyl N-(5-aminopentyl)carbamate, is a protected diamine with the molecular formula C11H24N2O2 and a molecular weight of 216.32 g/mol. This compound features a primary amine protected by a Boc group, making it a valuable building block in organic synthesis. It is widely employed as a linker in chemical biology and drug discovery, enabling the controlled conjugation of molecules.
- IUPAC
- N-Boc-1,5-diaminopentane,tert-Butyl N-(5-aminopentyl)carbamate
- Synonyms
- tert-Butyl N-(5-aminopentyl)carbamateN-(5-Aminopentyl)carbamic acid tert-butyl ester
Chemical Synthesis Building Block
N-Boc-cadaverine serves as a versatile intermediate in the synthesis of complex organic molecules. The Boc protecting group allows for selective reactions at the unprotected primary amine, followed by deprotection to reveal the second amine functionality.
Bifunctional Linker in Bioconjugation
Its diamine structure, with one amine selectively protected, makes N-Boc-cadaverine an ideal linker for bioconjugation. It can be used to connect biomolecules, peptides, or other entities in applications such as antibody-drug conjugates (ADCs) or diagnostic probes.
Drug Discovery and Medicinal Chemistry
This compound is utilised in medicinal chemistry to introduce flexible pentylamine spacers into drug candidates. This can influence pharmacokinetic properties, receptor binding, and overall drug efficacy.
Materials Science
N-Boc-cadaverine can be incorporated into polymers or surface modification strategies, where the amine functionalities can be used for subsequent cross-linking or attachment of other molecules.
| Molecular weight | 202.29 |
|---|---|
| Linear formula | (CH)3COCONH(CH2)5NH2 |
| Assay | ≥97.0% (NT) |
| Density | 0.972 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.460 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 109 °C / 228.2 °F |
| Transport (UN / ADR) | UN 2735PSN1 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Boc-cadaverine used for?
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N-Boc-cadaverine is primarily used as a building block in organic synthesis and as a bifunctional linker in chemical biology and drug discovery applications. It enables the controlled connection of molecules due to its protected amine functionality.
What is the CAS number and molecular formula for N-Boc-cadaverine?
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The CAS number for N-Boc-cadaverine is 51644-96-3. Its linear formula is (CH)3COCONH(CH2)5NH2.
What grade and purity does Tech Serve Solutions supply for N-Boc-cadaverine?
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Tech Serve Solutions supplies N-Boc-cadaverine with an assay of ≥97.0% (NT). We do not represent this product as USP, EP, BP, or any pharmacopoeia grade.
How should N-Boc-cadaverine be handled safely?
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N-Boc-cadaverine is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment including full-face respirators, chemical-resistant gloves, and goggles is essential. Handle in a well-ventilated area and seek immediate medical attention in case of exposure.
Is N-Boc-cadaverine a controlled substance?
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The provided data does not indicate that N-Boc-cadaverine is a controlled substance.
How is N-Boc-cadaverine shipped and exported by TSS?
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Tech Serve Solutions exports and ships N-Boc-cadaverine internationally. It is classified for transport as UN 2735, Class 8, Packing Group III.
How can I request a quote or sample of N-Boc-cadaverine?
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Please contact our sales team through the website or by phone to request a quote or a sample of N-Boc-cadaverine.
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