N-Boc-3-isothiocyanatopropylamine
N-Boc-3-isothiocyanatopropylamine (CAS: 286955-45-1; Formula: C9H16N2O2S; Molar Mass: 216.30 g/mol) is a valuable organic building block featuring a protected amine and a reactive isothiocyanate group. This bifunctional molecule is primarily utilised in chemical synthesis and chemical biology. Its unique structure allows for versatile derivatisation, making it an important intermediate for creating more complex molecules in research and development settings.
- IUPAC
- tert-Butyl N-(3-isothiocyanatopropyl)carbamate
Chemical Synthesis Intermediate
N-Boc-3-isothiocyanatopropylamine serves as a key intermediate in organic synthesis. The isothiocyanate moiety readily reacts with nucleophiles such as amines and alcohols, enabling the formation of thioureas and thiocarbamates respectively. The Boc-protected amine can be deprotected under acidic conditions to reveal a primary amine for further functionalisation.
Bioconjugation and Chemical Biology
The isothiocyanate group is a well-established functional handle for bioconjugation. It can be used to covalently label proteins, peptides, or other biomolecules containing primary amine groups, facilitating their detection, purification, or modification in chemical biology research.
Linker Chemistry
As a bifunctional linker, this compound can bridge two different molecular entities. The Boc-protected amine and the isothiocyanate group offer orthogonal reactivity, enabling sequential conjugation strategies. This is particularly useful in the development of complex chemical structures and probes.
| Molecular weight | 216.30 |
|---|---|
| Empirical formula | C9H16N2O2S |
| Assay | ≥97.0% (GC) |
| Melting point | 67-72 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
- P342
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 36/37/38-42 |
| Safety statements (S) | 22-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Boc-3-isothiocyanatopropylamine used for?
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N-Boc-3-isothiocyanatopropylamine is primarily used as a bifunctional linker and building block in chemical synthesis and chemical biology. Its isothiocyanate group reacts with nucleophiles, while the protected amine can be deprotected for further functionalisation.
What are the CAS number and formula for N-Boc-3-isothiocyanatopropylamine?
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The CAS number is 286955-45-1, and the empirical formula is C9H16N2O2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Boc-3-isothiocyanatopropylamine with an assay of ≥97.0% (GC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling considerations for this compound?
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This compound carries a Danger signal word with hazards including skin irritation (H315), eye irritation (H319), respiratory sensitisation (H334), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, faceshields, and gloves, must be worn. Ensure adequate ventilation and avoid dust formation.
How is N-Boc-3-isothiocyanatopropylamine packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports fine chemicals with adherence to all relevant international regulations, ensuring safe transit and handling. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or sample of N-Boc-3-isothiocyanatopropylamine, please contact our sales team through the website or by phone. We are happy to assist with your chemical needs.
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