N-(3-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide
N-(3-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide (CAS 113975-31-8; C10H13IN2O; molar mass 304.13 g/mol) is a halogenated heterocyclic building block: a 2-aminopyridine bearing a 3-iodo substituent and a pivaloyl (2,2-dimethylpropanoyl) amide. The pivalamide protects and directs the ring nitrogen while the aryl iodide serves as a reactive handle for palladium-catalysed cross-coupling and metal-halogen exchange. Tech Serve Solutions supplies it as a research-grade intermediate for medicinal and synthetic chemistry.
- Synonyms
- N-(3-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamideN-(3-Iodopyridin-2-yl)pivalamideN-(3-Iodo-2-pyridinyl)-2,2-dimethylpropanamide2,2-Dimethyl-N-(3-iodopyridin-2-yl)propanamide3-Iodo-2-(pivaloylamino)pyridineCAS 113975-31-8
Cross-coupling building block
The C3 aryl iodide is a versatile handle for palladium-catalysed Suzuki, Negishi, Stille and Sonogashira couplings, enabling carbon-carbon bond formation to elaborate substituted pyridine scaffolds.
Directed metalation and halogen exchange
The pivalamide acts as a directing and protecting group, while the iodide allows lithium- or magnesium-halogen exchange to generate reactive organometallics for further functionalisation.
Pharmaceutical and agrochemical intermediate
As a functionalised aminopyridine, it is used in discovery and process chemistry to construct fused heterocycles and pyridine-containing candidate molecules.
Heterocyclic scaffold synthesis
The adjacent amide and ortho-iodide are well suited to intramolecular cyclisation routes toward azaindoles, naphthyridines and related nitrogen heterocycles.
Laboratory research reagent
Supplied for method development and structure-activity studies in academic and industrial laboratories where a defined 3-iodo-2-pivalamidopyridine is required.
| Molecular weight | 304.13 |
|---|---|
| Empirical formula | C10H13IN2O |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(3-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide used for?
+
It is used mainly as a building block in organic and medicinal chemistry. The 3-iodo group enables palladium-catalysed cross-coupling and metal-halogen exchange, while the pivalamide protects and directs the ring nitrogen, making it valuable for assembling substituted and fused pyridine scaffolds.
What is the CAS number and molecular formula of N-(3-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide?
+
The CAS number is 113975-31-8 and the molecular formula is C10H13IN2O, with a molecular weight of 304.13 g/mol. The MDL number is MFCD05662384.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound as a research- and synthesis-grade building block. A specific assay is confirmed on the certificate of analysis for each lot; we do not represent it as USP, BP or EP pharmacopoeial grade. Please request current specifications for your intended use.
What are the safety and handling requirements?
+
It carries GHS07 with the signal word Warning and hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and adequate ventilation, avoid dust formation, and consult the Safety Data Sheet before use. Its German Water Hazard Class (WGK) is 3.
How is N-(3-Iodo-pyridin-2-yl)-2,2-dimethyl-propionamide packed, shipped and exported?
+
It is packed in tightly sealed containers appropriate to the quantity ordered, with full labelling and documentation. Tech Serve Solutions exports worldwide and provides a Certificate of Analysis and Safety Data Sheet, arranging compliant transport in line with applicable dangerous-goods and import requirements.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with your required quantity, packaging and destination, quoting CAS 113975-31-8. We will respond with availability, specifications and a formal quotation, and can arrange samples where appropriate.
▶ Related products
4-Amino-2-chloropyridine
C5H5ClN2
Heterocyclic Building Blocks
4-Ethynyl-1-methyl-1H-pyrazole
C6H6N2
Heterocyclic Building Blocks
4-Hydroxyquinoline-3-carboxylic acid ethyl ester
C12H11NO3
Heterocyclic Building Blocks
4-isocyanatopyridine
C6H4N2O
Heterocyclic Building Blocks
5-Chloro-2,8-dimethylquinoline
Heterocyclic Building Blocks
5-Chloro-2-methylene-1,3,3-trimethylindoline
Heterocyclic Building Blocks
5-Chloro-2-thiophenecarbonitrile
Heterocyclic Building Blocks
5-ethynyl-1H-pyrazole
C5H4N2
Heterocyclic Building Blocks▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis