N-(3-Iodo-pyridin-4-yl)-2,2-dimethyl-propionamide
N-(3-Iodo-pyridin-4-yl)-2,2-dimethyl-propionamide (CAS 113975-33-0; C10H13IN2O; molar mass 304.13 g/mol) is a halogenated pyridine building block in which a 4-aminopyridine carries a 3-iodo substituent and a pivaloyl (2,2-dimethylpropionamide) group on nitrogen. The pivalamide protects the amine and can direct ortho-metalation, while the aryl iodide serves as a reactive handle for palladium-catalysed cross-coupling. Tech Serve Solutions supplies it as a research-grade intermediate for synthesis.
- Synonyms
- N-(3-Iodo-pyridin-4-yl)-2,2-dimethyl-propionamideN-(3-Iodopyridin-4-yl)pivalamide2,2-Dimethyl-N-(3-iodopyridin-4-yl)propanamideN-(3-Iodo-4-pyridyl)pivalamideN-(3-Iodopyridin-4-yl)-2,2-dimethylpropanamideCAS 113975-33-0
Cross-coupling substrate
The aryl iodide is a reactive site for palladium-catalysed coupling, including Suzuki-Miyaura, Sonogashira, Heck and Stille reactions. This allows the controlled introduction of aryl, alkenyl and alkynyl groups at the 3-position of the pyridine ring.
Heterocyclic building block
It is used as a functionalised pyridine scaffold in multistep organic synthesis. The combination of a protected amino group and an ortho iodide makes it a convenient precursor to fused and substituted azaheterocycles.
Directed ortho-metalation and protected amine
The 2,2-dimethylpropionamide (pivalamide) masks the 4-amino group and can act as a directing group in metalation chemistry. After elaboration, the amide can be hydrolysed to regenerate the free aminopyridine.
Pharmaceutical and agrochemical research intermediate
As a halogenated heterocyclic intermediate, it supports discovery and process-route development in medicinal and agrochemical chemistry. We supply it for research and manufacturing use and make no therapeutic or efficacy claims.
| Molecular weight | 304.13 |
|---|---|
| Empirical formula | C10H13IN2O |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(3-Iodo-pyridin-4-yl)-2,2-dimethyl-propionamide used for?
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It is used mainly as a building block in organic synthesis. The aryl iodide enables palladium-catalysed cross-coupling (Suzuki, Sonogashira, Heck, Stille), while the pivalamide protects the 4-amino group and can direct ortho-metalation, making it a useful precursor to substituted and fused pyridine systems in pharmaceutical and agrochemical research.
What is the CAS number and molecular formula of N-(3-Iodo-pyridin-4-yl)-2,2-dimethyl-propionamide?
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The CAS number is 113975-33-0. The empirical formula is C10H13IN2O (Hill notation) with a molecular weight of 304.13 g/mol.
What grade and purity does Tech Serve Solutions supply?
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We supply this compound as a research/technical-grade synthesis intermediate. A current Certificate of Analysis with the actual assay and batch specification accompanies each lot on request. We do not represent it as USP, BP or EP pharmacopoeial grade.
How should N-(3-Iodo-pyridin-4-yl)-2,2-dimethyl-propionamide be handled and stored?
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Verified GHS hazard data was not supplied with this listing, so handle it as a potentially hazardous research chemical: use appropriate eye, skin and respiratory protection, work with adequate ventilation, and avoid dust, ingestion and inhalation. Store in a tightly closed container in a cool, dry, well-ventilated place away from incompatible materials. Always consult the Safety Data Sheet we provide before use.
How is N-(3-Iodo-pyridin-4-yl)-2,2-dimethyl-propionamide packed, shipped and exported?
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It is packed in appropriately labelled containers sized to the order, from gram quantities to bulk, with full identification and documentation. As a specialist exporter since 1998, Tech Serve Solutions arranges compliant international shipping with the relevant transport and customs paperwork for your destination.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and delivery destination, quoting CAS 113975-33-0. We will respond with current availability, specification, lead time and a formal quotation, along with the Certificate of Analysis and Safety Data Sheet.
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