N-(3-Iodo-4-methoxy-pyridin-2-yl)-2,2-dimethyl-propionamide
N-(3-Iodo-4-methoxy-pyridin-2-yl)-2,2-dimethyl-propionamide (CAS 898561-62-1; molecular formula C11H15IN2O2; molar mass 334.15 g/mol) is a halogenated pyridine building block in which a pivaloyl (2,2-dimethylpropanoyl) amide and a methoxy group flank a reactive carbon-iodine bond. It is used principally in chemical synthesis as an intermediate for transition-metal-catalysed cross-coupling and directed functionalisation. Tech Serve Solutions supplies it as a research-grade building block to pharmaceutical, agrochemical and fine-chemical laboratories worldwide.
- Synonyms
- N-(3-Iodo-4-methoxy-pyridin-2-yl)-2,2-dimethyl-propionamideN-(3-Iodo-4-methoxypyridin-2-yl)pivalamide2,2-Dimethyl-N-(3-iodo-4-methoxypyridin-2-yl)propanamideN-(3-Iodo-4-methoxy-2-pyridinyl)-2,2-dimethylpropanamideCAS 898561-62-1
Cross-coupling intermediate
The carbon-iodine bond on the pyridine ring is a versatile handle for palladium- or nickel-catalysed cross-couplings such as Suzuki-Miyaura, Negishi, Stille and Sonogashira reactions. This allows new carbon-carbon and carbon-heteroatom bonds to be installed at the 3-position.
Pharmaceutical and agrochemical building block
As a multifunctional pyridine scaffold it serves as an intermediate in the discovery and preparation of pharmaceutical and agrochemical candidates. The pre-installed methoxy and pivalamide groups provide defined regiochemistry for onward elaboration.
Directed metalation and functionalisation
The pivaloyl amide acts as both a protecting group for the ring nitrogen substituent and a directing group, supporting regioselective metalation and further functionalisation of the pyridine core.
Halogen-metal exchange
The iodide readily undergoes halogen-metal exchange with organolithium or organomagnesium reagents to generate a reactive organometallic species for reaction with electrophiles, extending the range of accessible derivatives.
Heterocyclic library synthesis
The compound is well suited to medicinal-chemistry and library synthesis where a substituted pyridine core with an orthogonal iodo handle is required for rapid analogue generation.
| Molecular weight | 334.15 |
|---|---|
| Empirical formula | C11H15IN2O2 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-(3-Iodo-4-methoxy-pyridin-2-yl)-2,2-dimethyl-propionamide used for?
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It is used mainly as a halogenated heterocyclic building block in chemical synthesis. The reactive carbon-iodine bond makes it valuable for transition-metal-catalysed cross-coupling and halogen-metal exchange, and it serves as an intermediate in pharmaceutical and agrochemical research.
What is the CAS number and molecular formula of N-(3-Iodo-4-methoxy-pyridin-2-yl)-2,2-dimethyl-propionamide?
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Its CAS number is 898561-62-1 and its empirical formula is C11H15IN2O2 (Hill notation), corresponding to a molecular weight of 334.15 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a research-grade building block for synthetic and laboratory use. We do not represent it as USP, BP or EP pharmacopoeial grade. A current Certificate of Analysis with the exact assay for each batch is available on request.
How should this compound be handled and stored safely?
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No GHS classification is provided in our current dataset, so it should be treated as a research chemical of unknown hazard. Handle it only with appropriate laboratory controls, gloves, eye protection and ventilation, store it tightly closed in a cool, dry place away from light and moisture, and consult the Safety Data Sheet supplied with your order before use.
How is N-(3-Iodo-4-methoxy-pyridin-2-yl)-2,2-dimethyl-propionamide packed, shipped and exported?
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It is packed in tightly sealed, labelled containers sized to the order, from gram quantities to bulk, with packaging chosen to protect the material in transit. Tech Serve Solutions exports worldwide with full documentation, including a Certificate of Analysis and Safety Data Sheet.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time and a formal quotation. Samples can be arranged for evaluation where stock permits.
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