Methyldiphenylphosphine oxide
Methyldiphenylphosphine oxide (CAS: 2129-89-7), with the chemical formula CH3P(C6H5)2(O) and a molecular weight of 216.22 g/mol, is a valuable organophosphorus compound. It serves as an effective catalyst in various organic transformations, including halogenation reactions under Appel conditions, hydrosilylation, and enantioselective cyanosilylation of ketones. This compound is a key reagent in synthetic chemistry, offering reliable performance in demanding catalytic applications.
- IUPAC
- Diphenylmethylphosphine oxide,Methyldiphenyloxophosphine,NSC 407134
- Synonyms
- Diphenylmethylphosphine oxideMethyldiphenyloxophosphineNSC 407134
Catalysis in Halogenation Reactions
Methyldiphenylphosphine oxide catalyses the chlorination and bromination of alcohols, particularly under the Appel reaction conditions. This facilitates the efficient conversion of hydroxyl groups into halide functionalities, a crucial step in many synthetic pathways.
Hydrosilylation Reactions
This phosphine oxide derivative acts as a catalyst in hydrosilylation reactions. These reactions are important for forming carbon-silicon bonds, widely used in the synthesis of silicon-containing materials and organic intermediates.
Enantioselective Cyanosilylation of Ketones
It plays a role in promoting the enantioselective cyanosilylation of ketones. This process is vital for the asymmetric synthesis of chiral cyanohydrins, valuable building blocks in pharmaceuticals and fine chemicals.
| Molecular weight | 216.22 |
|---|---|
| Linear formula | CH3P(C6H5)2(O) |
| Assay | 98% |
| Application | Catalyst for:• Chlorination and bromination (halogenation) of alcohols under Appel conditions1• Hydrosilylation reactions2• Enantioselective cyanosilylation of ketones3 |
| Melting point | 111-115 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyldiphenylphosphine oxide used for?
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Methyldiphenylphosphine oxide (CAS: 2129-89-7) is used as a catalyst in organic synthesis, notably for halogenation of alcohols under Appel conditions, hydrosilylation, and enantioselective cyanosilylation of ketones.
What are the CAS number and formula for Methyldiphenylphosphine oxide?
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The CAS number for Methyldiphenylphosphine oxide is 2129-89-7 and its chemical formula is CH3P(C6H5)2(O).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyldiphenylphosphine oxide with an assay of 98%. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should Methyldiphenylphosphine oxide be handled safely?
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Methyldiphenylphosphine oxide is harmful if swallowed, in contact with skin, or inhaled, and causes skin and eye irritation. Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be worn. Ensure good ventilation and avoid breathing dust. In case of contact, rinse immediately with plenty of water. For eye contact, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do.
How is Methyldiphenylphosphine oxide packed and exported?
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Methyldiphenylphosphine oxide is carefully packed to ensure stability and integrity during transit. As a global supplier, Tech Serve Solutions has extensive experience in exporting chemicals worldwide, adhering to all relevant shipping and customs regulations.
How can I request a sample or quote for Methyldiphenylphosphine oxide?
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To request a sample or a quote for Methyldiphenylphosphine oxide, please contact our sales team through the website or by calling us directly. We will be pleased to assist you with your inquiry.
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