Methyl dimethoxyacetate
Methyl dimethoxyacetate (CAS 89-91-8) is a versatile organic compound with the molecular formula (CH3O)2CHCOOCH3 and a molecular weight of 134.13 g/mol. As a key building block and ester, it plays a crucial role in various chemical synthesis applications. Its primary uses include serving as a precursor in Claisen acylations and as an acylating reagent for diverse substrates, contributing to the preparation of complex organic molecules.
- IUPAC
- Glyoxylic acid methyl ester dimethyl acetal
- Synonyms
- Glyoxylic acid methyl ester dimethyl acetal
Claisen Acylation Reagent
Methyl dimethoxyacetate is employed in Claisen acylation reactions involving active hydrogen compounds. This application allows for the introduction of a specific acyl group, facilitating the formation of new carbon-carbon bonds in organic synthesis.
Lithium Enolate Precursor
This compound serves as a valuable precursor for generating lithium enolates. These reactive intermediates are fundamental in numerous carbon-carbon bond-forming reactions, enabling the synthesis of complex molecular architectures.
Acylating Agent for Cycloalkanones and Amino Alcohols
It functions as an effective acylating agent for cycloalkanone enolates and amino alcohols. This capability is vital in modifying functional groups and building more elaborate structures in multi-step organic syntheses.
Synthesis of Spirocyclic Compounds
Methyl dimethoxyacetate has been utilised in the preparation of specific substituted tetroxaspiro[5.5] undecane derivatives. This highlights its utility in constructing unique spirocyclic ring systems.
| Molecular weight | 134.13 |
|---|---|
| Linear formula | (CH3O)2CHCOOCH3 |
| Assay | 97% |
| Boiling point | 67 °C/18 mmHg(lit.) |
| Density | 1.096 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.405(lit.) |
| Storage temperature | 2-8°C |
| Application | Methyl dimethoxyacetate has been used:• in Claisen acylation of active hydrogen compounds1• in preparation of 3, 9-disubstituted 2,4,8,10-tetroxaspiro [5.5] undecane2• as Lithium enolate precursor3 • as acylating reagent for cycloalkanone enolates4 and amino alcohols5 |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 67 °C / 152.6 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl dimethoxyacetate used for?
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Methyl dimethoxyacetate is primarily used in organic synthesis as a reagent for Claisen acylations, as a precursor for lithium enolates, and as an acylating agent for various organic compounds, including cycloalkanones and amino alcohols. It is also used in the synthesis of spirocyclic compounds.
What are the CAS number and formula for Methyl dimethoxyacetate?
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The CAS number for Methyl dimethoxyacetate is 89-91-8, and its linear formula is (CH3O)2CHCOOCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl dimethoxyacetate with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
What are the safety and handling recommendations for Methyl dimethoxyacetate?
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Methyl dimethoxyacetate is a combustible liquid with a flash point of 67°C (152.6°F). Recommended personal protective equipment includes eyeshields, gloves, and appropriate respiratory protection (half-mask respirator). Store at temperatures between 2-8°C.
How is Methyl dimethoxyacetate packed, shipped, and exported?
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Tech Serve Solutions professionally packs and exports fine chemicals globally, adhering to all necessary regulations for safe and compliant transportation.
How can I request a sample or quote for Methyl dimethoxyacetate?
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To request a sample or a quote for Methyl dimethoxyacetate, please contact our sales team through our website or by phone.
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