Methyl dichlorophosphite
Methyl dichlorophosphite (CAS: 3279-26-3), with the molecular formula CH3OPCl2 and a molecular weight of 132.91 g/mol, is a reactive organophosphorus compound. It serves as a valuable intermediate in organic synthesis. Its primary applications include the preparation of various phosphorus-containing compounds, such as phosphonates, phosphites, and oxazaphosphorinanes, essential in pharmaceutical research and material science.
- IUPAC
- Methyl phosphorodichloridite
- Synonyms
- Methyl phosphorodichloridite
Synthesis of Phosphonamidate and Phosphonate-Linked Phosphonopeptides
Methyl dichlorophosphite is utilized in the synthesis of phosphonamidate- and phosphonate-linked phosphonopeptides, crucial for developing novel therapeutic agents.
Preparation of Organophosphorus Derivatives
It serves as a key reagent for preparing derivatives like 2-(2-iodophenyl)ethyl methyl phosphite and various oxazaphosphorinanes, expanding the scope of phosphorus chemistry.
Oligonucleotide Synthesis
This compound has been employed in the synthesis of deoxyoligonucleotides on polymer supports, contributing to advancements in nucleic acid research and therapeutics.
Formation of Phosphorodichloridothioates
Methyl dichlorophosphite is a precursor in the formation of phosphorodichloridothioates, important intermediates in the synthesis of organothiophosphorus compounds.
| Molecular weight | 132.91 |
|---|---|
| Linear formula | CH3OPCl2 |
| Boiling point | 93-95 °C(lit.) |
| Density | 1.376 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.474(lit.) |
| Application | Methyl dichlorophosphite has been employed in the preparation of:• phosphonamidate- and phosphonate-linked phosphonopeptides1• 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol2• deoxyoligonucleotides on a polymer support3• cis- and trans-2-oxo-2-propionyl-1,3,2-oxazaphosphorinane4• phosphorodichloridothioates5 • oxazaphosphorinanes6 |
| Melting point | −91 °C(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 25 °C / 77 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-14-34-37 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl dichlorophosphite used for?
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Methyl dichlorophosphite is used as a building block and intermediate in organic synthesis, particularly for preparing phosphonates, phosphonopeptides, deoxyoligonucleotides, and oxazaphosphorinanes.
What are the CAS number and chemical formula for Methyl dichlorophosphite?
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The CAS number for Methyl dichlorophosphite is 3279-26-3, and its linear chemical formula is CH3OPCl2.
What grade and purity does Tech Serve Solutions supply for Methyl dichlorophosphite?
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Tech Serve Solutions supplies Methyl dichlorophosphite typically at a purity suitable for research and chemical synthesis. Specific assay details are available upon request. It is not supplied as USP, BP, or EP grade.
How should Methyl dichlorophosphite be handled safely?
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Methyl dichlorophosphite is a corrosive and flammable liquid that reacts violently with water. Handle with extreme caution in a well-ventilated area, wearing appropriate personal protective equipment including gloves, eye protection (face shield and goggles), and respiratory protection. Avoid contact with water, moisture, and ignition sources.
Is Methyl dichlorophosphite packed, shipped, or exported by TSS?
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Yes, Tech Serve Solutions reliably packs, ships, and exports Methyl dichlorophosphite globally, adhering to all relevant transportation and safety regulations.
How can I request a quote or sample for Methyl dichlorophosphite?
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To request a quote or a sample of Methyl dichlorophosphite, please contact the Tech Serve Solutions sales team through our website or by direct inquiry, providing your specific requirements.
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