Methyl difluoroacetate
Methyl difluoroacetate (CAS 433-53-4), with the linear formula F₂CHCO₂CH₃ and a molecular weight of 110.06 g/mol, is a fluorinated ester. It is primarily utilised as a building block in chemical synthesis and for specialised applications in electrochemistry. Notably, it has been investigated for its efficacy in improving the performance and stability of lithium-ion battery electrolytes, including its role in inhibiting cathode current collector corrosion.

Lithium-ion Battery Electrolyte Component
Methyl difluoroacetate has demonstrated utility in the formulation of electrolytes for lithium-ion cells. Its inclusion has been shown to provide good inhibition of aluminium cathode current collector corrosion, contributing to enhanced battery longevity and performance.
Enhancing Electrolyte Thermal Stability
This compound serves as an electrolyte solvent, contributing to the improvement of thermal stability in lithium-ion batteries. This property is critical for safe and reliable operation under various temperature conditions.
Fluorinated Building Block
As a difluoromethylated ester, Methyl difluoroacetate is a valuable building block in organic synthesis. It enables the introduction of the difluoromethyl group into more complex molecules for diverse chemical research and development purposes.
| Molecular weight | 110.06 |
|---|---|
| Linear formula | F2CHCO2CH3 |
| Assay | 96% |
| Boiling point | 85-86 °C(lit.) |
| Density | 1.26 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.334(lit.) |
| Application | Methyl difluoroacetate has been used:• to compose the electrolyte for Lithium ion cells, also showed good inhibition of aluminum cathode current collector corrosion1• as electrolyte solvent for improvement of thermal stability in lithium-ion batteries2 |


Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 23 °C / 73.4 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-20/21/22-36/37/38 |
| Safety statements (S) | 16-23-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl difluoroacetate used for?
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Methyl difluoroacetate is primarily used as a building block in chemical synthesis and has applications in improving the performance and stability of lithium-ion battery electrolytes, including inhibiting cathode corrosion and enhancing thermal stability.
What is the CAS number and formula for Methyl difluoroacetate?
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The CAS number for Methyl difluoroacetate is 433-53-4 and its linear formula is F₂CHCO₂CH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl difluoroacetate with a minimum assay of 96%. This product is supplied for research and industrial use and is not represented as USP, BP, or EP grade.
How should Methyl difluoroacetate be handled safely?
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Methyl difluoroacetate is a flammable liquid and vapour (H226). It is harmful if swallowed, inhaled, or in contact with skin (H302, H332, H312), and causes skin and serious eye irritation (H315, H319). It may also cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection (e.g., type ABEK respirator filter), should be used. Handle in a well-ventilated area.
Is Methyl difluoroacetate a controlled substance?
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Based on the provided data, Methyl difluoroacetate is not classified as a controlled substance. However, users should always consult local regulations.
How is Methyl difluoroacetate packed, shipped, and exported?
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Methyl difluoroacetate is shipped in accordance with UN 1993 regulations for flammable liquids. We export globally, adhering to all relevant international shipping and customs requirements.
How can I request a quote or sample of Methyl difluoroacetate?
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To request a quote or a sample, please contact our sales department via the website or direct email, providing your contact details and the quantity required.
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